Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.48 |
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628000 | 0.81 | MAPT (0.42) | MAPTTHRBRXFP1GAALMNA | |
| SCHEMBL625664 | 0.76 | MAPT (0.58) | MAPTTHRBRXFP1 | |
| SCHEMBL627054 | 0.76 | KDM4E (0.48) | MAPTTHRBRXFP1KDM4ELMNA | |
| SCHEMBL628100 | 0.76 | MAPT (0.54) | MAPTTHRBGAAKDM4ELMNA | |
| SCHEMBL626106 | 0.73 | THRB (0.49) | MAPTTHRBRXFP1GAA | |
| SCHEMBL628264 | 0.71 | BTK (0.51) | MAPTTHRB | |
| SCHEMBL21724996 | 0.69 | SMN1; SMN2 (0.49) | MAPTKDM4ELMNAMEN1KMT2A | |
| SCHEMBL15164461 | 0.69 | SMN1; SMN2 (0.47) | MAPTKDM4ELMNAMEN1KMT2A | |
| SCHEMBL627088 | 0.68 | MAPT (0.32) | MAPTTHRB | |
| SCHEMBL1700325 | 0.68 | HPGD (0.62) | MAPTKDM4ELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |