Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 6/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8823098 | 0.86 | GABRA2 (0.51) | GABRA2GABRB2CYP19A1ALDH1A1CYP3A4 | |
| SCHEMBL7988458 | 0.79 | GABRA2 (0.49) | GABRA2GABRB2CYP19A1ALDH1A1CYP2C9 | |
| SCHEMBL6257997 | 0.78 | CYP1A2 (0.62) | GABRA2GABRB2ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL20027816 | 0.78 | CYP19A1 (0.68) | CYP19A1ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL20028096 | 0.78 | CYP19A1 (0.54) | GABRA2GABRB2CYP19A1ALDH1A1CYP3A4 | |
| SCHEMBL10057637 | 0.78 | ALDH1A1 (0.55) | CYP19A1ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10679185 | 0.78 | CYP2C9 (0.65) | GABRA2GABRB2CYP19A1ALDH1A1CYP3A4 | |
| SCHEMBL31526177 | 0.77 | GABRA2 (0.56) | GABRA2GABRB2ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL3494358 | 0.77 | ALDH1A1 (0.54) | GABRA2GABRB2CYP19A1ALDH1A1CYP3A4 | |
| SCHEMBL25261894 | 0.77 | MAPT (0.51) | GABRA2GABRB2CYP19A1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005066137-A1 | 2,5-DIARYL-1H-IMIDAZOLE-4-CARBOXAMIDES AS NEUROKININ-3 RECEPTOR MODULATORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES | NEUROGEN CORPORATION (US) | 2005-07-21 | — | — | WO | disclosed |
| US-20050148601-A1 | Neurokinin-3 receptor modulators: diaryl imidazole derivatives | NEUROGEN CORPORATION | 2005-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148601-A1 | Neurokinin-3 receptor modulators: diaryl imidazole derivatives | TACR1, TACR2, TACR3 | GABRA2 351/4885GABRB2 374/4885CYP19A1 1889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.