Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGAV | P06756 | 1/20 | 0.45 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909277 | 1.00 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1CA2NPSR1CNR1 | |
| SCHEMBL5909307 | 0.84 | VNN1 (0.52) | ALDH1A1CNR1CNR2 | |
| SCHEMBL5909193 | 0.84 | VNN1 (0.52) | ALDH1A1CNR1CNR2 | |
| SCHEMBL6203421 | 0.84 | VNN1 (0.52) | ALDH1A1CNR1CNR2 | |
| SCHEMBL5909232 | 0.84 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1CNR1CNR2LMNA | |
| SCHEMBL5909226 | 0.83 | GAA (0.63) | ALDH1A1CA2CNR1CNR2LMNA | |
| SCHEMBL5909293 | 0.83 | GAA (0.63) | ALDH1A1CA2CNR1CNR2LMNA | |
| SCHEMBL5909188 | 0.83 | GAA (0.63) | ALDH1A1CA2CNR1CNR2LMNA | |
| SCHEMBL6787910 | 0.82 | CA2 (0.75) | ALDH1A1L3MBTL1CA2NPSR1TDP1 | |
| SCHEMBL5537767 | 0.82 | CA2 (0.75) | ALDH1A1L3MBTL1CA2NPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494672-A1 | AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY | Abbott Laboratories (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003086398-A1 | AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY | ABBOTT LABORATORIES (US) | 2003-10-23 | — | — | WO | disclosed |