Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625128 | 0.88 | CCNA2 (0.46) | PIK3CAMAP3K12SYKMAP4K1GPR119 | |
| SCHEMBL626582 | 0.87 | PIK3CA (0.42) | MAPTPIK3CAMAP3K12PIK3CDPIK3CB | |
| SCHEMBL625673 | 0.86 | MAP3K12 (0.48) | PIK3CAMAP3K12MAP4K1 | |
| SCHEMBL624984 | 0.86 | PIK3CA (0.48) | PIK3CA | |
| SCHEMBL627611 | 0.84 | MAP3K12 (0.43) | PIK3CAMAP3K12PIK3CDPIK3CBPIK3CG | |
| SCHEMBL628029 | 0.83 | F2RL3 (0.49) | KDM4EMAPTPRMT5HPGDMEN1 | |
| SCHEMBL626460 | 0.83 | MAPT (0.46) | KDM4EMAPTPRMT5HPGDMEN1 | |
| SCHEMBL624922 | 0.83 | PIK3CA (0.42) | PIK3CAMAP3K12MAP4K1GPR119 | |
| SCHEMBL626702 | 0.82 | MAP3K12 (0.43) | PIK3CAMAP3K12PIK3CDPIK3CBPIK3CG | |
| SCHEMBL625408 | 0.82 | MAP4K1 (0.39) | PIK3CAMAP3K12SYKMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |