Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 11/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625673 | 0.87 | MAP3K12 (0.48) | PIK3CAMAP3K12 | |
| SCHEMBL624985 | 0.87 | KDM4E (0.40) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 | |
| SCHEMBL626581 | 0.86 | FYN (0.47) | PIK3CAPIK3CDPIK3CBPIK3CGSCD | |
| SCHEMBL627611 | 0.84 | MAP3K12 (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 | |
| SCHEMBL626702 | 0.84 | MAP3K12 (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 | |
| SCHEMBL626135 | 0.84 | PIK3CA (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 | |
| SCHEMBL626299 | 0.81 | PIK3CA (0.47) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 | |
| SCHEMBL624042 | 0.79 | PIM1 (0.48) | — | |
| SCHEMBL627328 | 0.79 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 | |
| SCHEMBL624428 | 0.78 | MAP3K12 (0.47) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |