Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6279165 | 0.88 | ABL1 (0.44) | CSNK1A1CLK4ABL1PDGFRACDK7 | |
| SCHEMBL6277021 | 0.81 | BCHE (0.39) | CSNK1A1CLK4BCHENPY5RHPGD | |
| SCHEMBL6280307 | 0.74 | KDM4E (0.57) | CSNK1A1CLK4ABL1PDGFRACDK7 | |
| SCHEMBL6279167 | 0.70 | KDR (0.39) | ABL1BCHEHPGDMEN1KMT2A | |
| SCHEMBL6285208 | 0.67 | KDM4E (0.46) | CSNK1A1CLK4ABL1PDGFRACDK7 | |
| SCHEMBL16331371 | 0.64 | GRK5 (0.50) | BCHEKDM4EHSD17B10MAPK14FLT3 | |
| SCHEMBL32665254 | 0.63 | ALDH1A1 (0.51) | HPGDMEN1KMT2AHSD11B1ALDH1A1 | |
| SCHEMBL30429856 | 0.62 | DCLK1 (0.61) | CSNK1A1CLK4NPY5RHPGDKMO | |
| SCHEMBL2163999 | 0.62 | DCLK1 (0.61) | CSNK1A1CLK4NPY5RHPGDKMO | |
| SCHEMBL22148214 | 0.60 | MAP4K4 (0.44) | CSNK1A1CLK4ABL1PDGFRACDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921762-B2 | Substituted indolizine-like compounds and methods of use | AMGEN INC. (US) | 2005-07-26 | — | — | US | disclosed |