Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6277021 | 0.89 | BCHE (0.39) | BCHEKMOHPGDLMNAMEN1 | |
| SCHEMBL6279165 | 0.82 | ABL1 (0.44) | KDRBCHEMETKMONISCH | |
| SCHEMBL6280310 | 0.75 | KDM4E (0.46) | HPGDKDM4ERAB9A | |
| SCHEMBL6277017 | 0.70 | CSNK1A1 (0.47) | BCHEKMOABL1HPGDLMNA | |
| SCHEMBL3878881 | 0.68 | KMO (0.45) | KDRMETKMONISCHABL1 | |
| SCHEMBL18433062 | 0.68 | MAPK10 (0.59) | KDRBCHELMNAMEN1MAPT | |
| SCHEMBL3877279 | 0.67 | KMO (0.47) | KDRMETKMONISCHABL1 | |
| SCHEMBL1924861 | 0.65 | KDR (0.40) | KDRMETKMOABL1TGFBR1 | |
| SCHEMBL27531149 | 0.63 | MAPKAPK2 (0.49) | KDRBCHEKMONISCHTGFBR1 | |
| SCHEMBL6285213 | 0.62 | HTT (0.38) | KDRABL1ADORA2AHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921762-B2 | Substituted indolizine-like compounds and methods of use | AMGEN INC. (US) | 2005-07-26 | — | — | US | disclosed |