Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6277017 | 0.88 | CSNK1A1 (0.47) | ABL1PDGFRACSNK1A1CDK7BTK | |
| SCHEMBL6279167 | 0.82 | KDR (0.39) | ABL1KDRBCHEKMOTGFBR1 | |
| SCHEMBL6280307 | 0.73 | KDM4E (0.57) | ABL1PDGFRACSNK1A1CDK7BTK | |
| SCHEMBL6277021 | 0.70 | BCHE (0.39) | CSNK1A1CLK4BCHEKMOMAPK14 | |
| SCHEMBL27531149 | 0.68 | MAPKAPK2 (0.49) | KDRBCHEKMOTGFBR1EPHB4 | |
| SCHEMBL16331578 | 0.66 | GRK5 (0.60) | MAPK14TGFBR1METKMT2AKDM4E | |
| SCHEMBL3878881 | 0.64 | KMO (0.45) | ABL1KDRKMOMAPK14EPHB4 | |
| SCHEMBL18433062 | 0.64 | MAPK10 (0.59) | KDRBCHEMAPK14KCNH2AOC3 | |
| SCHEMBL16331371 | 0.64 | GRK5 (0.50) | KDRBCHEMAPK14FLT3GSK3B | |
| SCHEMBL6285208 | 0.64 | KDM4E (0.46) | ABL1PDGFRACSNK1A1CDK7BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921762-B2 | Substituted indolizine-like compounds and methods of use | AMGEN INC. (US) | 2005-07-26 | — | — | US | disclosed |