Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6061919 | 0.97 | NOS3 (0.37) | NOS3NOS1NOS2GABRA1GABRG2 | |
| Hydrochloric Acid SCHEMBL6909112 | 0.85 | GABRA1 (0.33) | GABRA1GABRG2GABRB3TAAR1GABRB2 | |
| Hydrochloric Acid SCHEMBL7764129 | 0.82 | GABRA1 (0.33) | GABRA1GABRG2GABRB3TAAR1GABRB2 | |
| Hydrochloric Acid SCHEMBL7149371 | 0.82 | GABRA1 (0.33) | GABRA1GABRG2GABRB3TAAR1GABRB2 | |
| SCHEMBL932704 | 0.81 | GABRA1 (0.35) | GABRA1GABRG2GABRB3TAAR1GABRB2 | |
| SCHEMBL18544054 | 0.77 | BACE1 (0.33) | GABRA1GABRG2GABRB3LMNATSHR | |
| Hydrochloric Acid SCHEMBL7095603 | 0.77 | CYP2C9 (0.45) | LMNAHPGD | |
| SCHEMBL5362668 | 0.76 | CYP2C9 (0.47) | NOS1NOS2SIGMAR1LMNAHPGD | |
| SCHEMBL18543890 | 0.75 | TSHR (0.35) | GABRA1GABRG2GABRB3GABRB2FAAH | |
| Hydrochloric Acid SCHEMBL5603772 | 0.74 | L3MBTL1 (0.41) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556317-A1 | SELECTIVE ISOMERIZATION AND LINEAR DIMERIZATION OF ALPHA-OLEFINS USING COBALT CATALYSTS | Chevron Phillips Chemical Company LP (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004033398-A1 | SELECTIVE ISOMERIZATION AND LINEAR DIMERIZATION OF ALPHA-OLEFINS USING COBALT CATALYSTS | CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) | 2004-04-22 | — | — | WO | disclosed |