Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625205 | 0.90 | F2RL3 (0.53) | F2RL3PIM1 | |
| SCHEMBL624533 | 0.89 | PIM1 (0.53) | KDM4EMAPTPKMPIM1PRMT5 | |
| SCHEMBL624058 | 0.88 | JAK2 (0.47) | TGFBR1KDM4EMAPTPKMPIM1 | |
| SCHEMBL626983 | 0.87 | CETP (0.44) | KDM4EMAPTPKMPRMT5KDM1A | |
| SCHEMBL17004610 | 0.86 | F2RL3 (0.57) | F2RL3PIM1 | |
| SCHEMBL623847 | 0.84 | F2RL3 (0.52) | F2RL3PIM1MEN1KMT2A | |
| SCHEMBL628028 | 0.83 | FYN (0.56) | TGFBR1KDM4EPKMPIM1CCNA2 | |
| SCHEMBL623578 | 0.83 | F2RL3 (0.48) | F2RL3PIM1MEN1ALDH1A1KMT2A | |
| SCHEMBL624985 | 0.83 | KDM4E (0.40) | KDM4EMAPTPRMT5SYKMEN1 | |
| SCHEMBL624031 | 0.83 | F2RL3 (0.50) | F2RL3PIM1GAAACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |