SCHEMBL6280772

SCHEMBL6280772

CC(CO)c1ccccc1C(C)COO

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.39
TRPA1 O75762 5/20 0.37
GABRA1 P14867 3/20 0.36
GABRG2 P18507 2/20 0.36
GABRB3 P28472 2/20 0.36
ALDH1A1 P00352 1/20 0.36
GABRB2 P47870 2/20 0.34
LMNA P02545 3/20 0.34
CYP1A2 P05177 3/20 0.33
KDM4E B2RXH2 1/20 0.33
AGTR1 P30556 1/20 0.33
ABCB11 O95342 1/20 0.33
CYP3A4 P08684 2/20 0.32
FAAH O00519 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
HPGD P15428 1/20 0.31
GABRB1 P18505 1/20 0.31
PTGS1 P23219 1/20 0.31
SLC6A2 P23975 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6284650 0.92 TSHR (0.45) TSHRTRPA1GABRA1GABRG2GABRB3
SCHEMBL3043989 0.85 TSHR (0.50) TSHRTRPA1GABRA1GABRG2GABRB3
SCHEMBL8578308 0.75 ABCB11 (0.46) TSHRTRPA1ALDH1A1ABCB11CYP3A4
SCHEMBL15328802 0.73 AGTR1 (0.50) TSHRLMNACYP1A2AGTR1ABCB11
SCHEMBL15328772 0.73 AGTR1 (0.50) TSHRLMNACYP1A2AGTR1ABCB11
SCHEMBL8580830 0.72 TAAR1 (0.52) TRPA1ALDH1A1LMNAKDM4E
SCHEMBL8567525 0.72 TSHR (0.72) TSHRTRPA1GABRA1GABRG2GABRB3
SCHEMBL593086 0.72 ESR1 (0.46) TSHRTRPA1GABRA1GABRG2GABRB3
SCHEMBL11291206 0.72 ALDH1A1 (0.42) TSHRTRPA1GABRA1GABRG2GABRB3
SCHEMBL25009948 0.71 TSHR (0.42) TSHRTRPA1GABRA1GABRG2GABRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2005314269-A METHOD FOR JOINTLY PRODUCING DIHYDROXYBENZENE AND DIISOPROPENYLBENZENE SUMITOMO CHEMICAL CO LTD 2005-11-10 JP disclosed