Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL9066399 | 0.92 | ALDH1A1 (0.42) | ALDH1A1TSHRHTTLMNAPOLB | |
| Tetrahydrofuran SCHEMBL8066439 | 0.92 | ALDH1A1 (0.44) | ALDH1A1TSHRHTTLMNAPOLB | |
| Tetrahydrofuran SCHEMBL28621953 | 0.92 | ALDH1A1 (0.44) | ALDH1A1TSHRHTTLMNAPOLB | |
| Tetrahydrofuran SCHEMBL2114570 | 0.92 | ALDH1A1 (0.50) | ALDH1A1TSHRHTTLMNAPOLB | |
| Tetrahydrofuran SCHEMBL139042 | 0.92 | ALDH1A1 (0.50) | ALDH1A1TSHRHTTLMNAPOLB | |
| Tetrahydrofuran SCHEMBL3966212 | 0.92 | ALDH1A1 (0.50) | ALDH1A1TSHRHTTLMNAPOLB | |
| Ether SCHEMBL4417828 | 0.89 | ALDH1A1 (0.47) | ALDH1A1TSHRHTTLMNAPOLB | |
| Ether SCHEMBL1559716 | 0.89 | ALDH1A1 (0.47) | ALDH1A1TSHRHTTLMNAPOLB | |
| Ether SCHEMBL463356 | 0.89 | ALDH1A1 (0.47) | ALDH1A1TSHRHTTLMNAPOLB | |
| Dioxane SCHEMBL8034299 | 0.89 | ALDH1A1 (0.47) | ALDH1A1TSHRHTTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6914140-B1 | Asymmetric synthesis process | HOFFMANN-LA ROCHE INC. (US) | 2005-07-05 | — | — | US | disclosed |