Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 18/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624016 | 0.86 | PIM1 (0.49) | BTK | |
| SCHEMBL625035 | 0.83 | THRB (0.48) | MAPTTHRBGAA | |
| SCHEMBL625777 | 0.83 | MAPT (0.56) | MAPTPOLBTHRBLMNATP53 | |
| SCHEMBL625501 | 0.82 | PIM1 (0.43) | — | |
| SCHEMBL624450 | 0.82 | PIM1 (0.54) | MAPTPOLBTHRBLMNATP53 | |
| SCHEMBL623999 | 0.80 | MAPT (0.55) | MAPTPOLBTHRBLMNATP53 | |
| SCHEMBL625742 | 0.80 | THRB (0.43) | MAPTPOLBTHRB | |
| SCHEMBL628264 | 0.79 | BTK (0.51) | MAPTPOLBBTKTHRB | |
| SCHEMBL624528 | 0.77 | CYP3A4 (0.41) | MAPTTHRB | |
| SCHEMBL625512 | 0.77 | THRB (0.44) | MAPTTHRBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |