Sulfotep

Sulfotep

SCHEMBL628316

CCCC.CCOP(=S)(OCC)OP(=S)(OCC)OCC.O=P(O)(O)O

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Sulfotep. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 2/20 0.45
TSHR P16473 3/20 0.40
TDP1 Q9NUW8 2/20 0.37
TP53 P04637 1/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
LPAR3 Q9UBY5 7/20 0.34
LPAR2 Q9HBW0 5/20 0.34
LPAR1 Q92633 2/20 0.34
ALDH1A1 P00352 2/20 0.33
CYP3A4 P08684 1/20 0.33
MAPK1 P28482 1/20 0.33
HSD17B10 Q99714 1/20 0.33
KDM4E B2RXH2 1/20 0.32
POLB P06746 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sulfotep SCHEMBL9561665 0.98 PPARD (0.43) PPARDTSHRTDP1TP53MEN1
Sulfotep SCHEMBL740515 0.95 PPARD (0.48) PPARDTSHRTDP1TP53MEN1
Sulfotep SCHEMBL2696245 0.93 PPARD (0.46) PPARDTSHRTDP1TP53MEN1
Sulfotep SCHEMBL7414347 0.88 TDP1 (0.43) PPARDTSHRTDP1TP53MEN1
Sulfotep SCHEMBL15687409 0.86 PPARD (0.45) PPARDTSHRTDP1TP53MEN1
Sulfotep SCHEMBL1419342 0.83 ALOX15 (0.34) PPARDTSHRTDP1TP53MEN1
Sulfotep SCHEMBL11362244 0.83 MEN1 (0.34) PPARDTSHRTDP1TP53MEN1
Sulfotep SCHEMBL8191946 0.83 TDP1 (0.46) PPARDTSHRTDP1TP53MEN1
Sulfotep SCHEMBL35637 0.83 TDP1 (0.46) PPARDTSHRTDP1TP53MEN1
Sulfotep SCHEMBL461502 0.81 TDP1 (0.39) PPARDTSHRTDP1TP53MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8518281-B2 Acid-resistance promoting composition CITIBANK, N.A. 2013-08-27 US claimed
EP-2304079-B1 ACID-RESISTANCE PROMOTING COMPOSITION MACDERMID INC (US) 2012-02-22 EP claimed
EP-2304079-A1 ACID-RESISTANCE PROMOTING COMPOSITION MacDermid, Incorporated (US) 2011-04-06 EP claimed
WO-2009148690-A1 ACID-RESISTANCE PROMOTING COMPOSITION MACDERMID, INCORPORATED (US) 2009-12-10 WO claimed
US-20090294294-A1 Acid-resistance promoting composition CITIBANK, N.A. 2009-12-03 US claimed
US-8518281-B2 Acid-resistance promoting composition CITIBANK, N.A. 2013-08-27 US disclosed
EP-2304079-B1 ACID-RESISTANCE PROMOTING COMPOSITION MACDERMID INC (US) 2012-02-22 EP disclosed
EP-2304079-A1 ACID-RESISTANCE PROMOTING COMPOSITION MacDermid, Incorporated (US) 2011-04-06 EP disclosed
WO-2009148690-A1 ACID-RESISTANCE PROMOTING COMPOSITION MACDERMID, INCORPORATED (US) 2009-12-10 WO disclosed
US-20090294294-A1 Acid-resistance promoting composition CITIBANK, N.A. 2009-12-03 US disclosed
EP-0325617-B1 THIOLENE COMPOSITIONS BASED ON BICYCLIC 'ENE COMPOUNDS LOCTITE CORPORATION (US) 1993-04-28 EP disclosed
EP-0338616-A1 Thiolene compositions based on bicyclic 'ene compounds LOCTITE CORPORATION (US) 1989-10-25 EP disclosed
EP-0325617-A1 THIOLENE COMPOSITIONS BASED ON BICYCLIC 'ENE COMPOUNDS. LOCTITE CORP (US) 1989-08-02 EP disclosed
US-4808638-A CROSSLINKING WITH POLYMERCAPTANS LOCTITE CORPORATION (US) 1989-02-28 US disclosed
WO-1988002902-A2 THIOLENE COMPOSITIONS BASED ON BICYCLIC 'ENE COMPOUNDS LOCTITE CORPORATION (US) 1988-04-21 WO disclosed