Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | CASP9 | P55211 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | TGM2 | P21980 | 5/20 | 0.50 |
| ▸ | CES1 | P23141 | 3/20 | 0.50 |
| ▸ | KIF11 | P52732 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9512923 | 0.76 | ALDH1A1 (0.61) | MEN1ALDH1A1MAPTALOX15KMT2A | |
| SCHEMBL29204334 | 0.76 | ALDH1A1 (0.61) | MEN1ALDH1A1MAPTALOX15KMT2A | |
| Hydrochloric Acid SCHEMBL11750902 | 0.75 | ALDH1A1 (0.56) | MEN1ALDH1A1MAPTALOX15KMT2A | |
| Hydrochloric Acid SCHEMBL11750895 | 0.75 | ALDH1A1 (0.56) | MEN1ALDH1A1MAPTALOX15KMT2A | |
| SCHEMBL4851463 | 0.74 | CHEK1 (0.56) | MEN1ALDH1A1MAPTALOX15KMT2A | |
| SCHEMBL5631829 | 0.74 | ALDH1A1 (0.54) | MEN1ALDH1A1MAPTALOX15KMT2A | |
| SCHEMBL14983928 | 0.74 | ALDH1A1 (0.54) | MEN1ALDH1A1MAPTALOX15KMT2A | |
| SCHEMBL31175908 | 0.73 | CASP3 (1.00) | CASP3CASP1CASP7CASP9 | |
| SCHEMBL6535562 | 0.73 | CASP3 (1.00) | CASP3CASP1CASP7CASP9 | |
| SCHEMBL9098720 | 0.72 | GAA (0.57) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906090-B1 | Compositions and methods for treating mycobacterial diseases | ASTRAZENECA AB (SE) | 2005-06-14 | — | — | US | disclosed |
| EP-1058548-B1 | THE USE OF ISATIN AND OXINDOLE DERIVATIVES IN THE PREPARATION OF A MEDICAMENT FOR USE IN THE TREATMENT OF MYCOBACTERIAL DISEASE | ASTRAZENECA AB (SE) | 2003-09-17 | — | — | EP | disclosed |
| EP-1058548-A1 | NEW USE | AstraZeneca AB (SE) | 2000-12-13 | — | — | EP | disclosed |
| WO-1999044608-A1 | NEW USE | ASTRAZENECA AB (SE) | 1999-09-10 | — | — | WO | disclosed |