Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.67 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.67 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.67 |
| ▸ | PRKACA | P17612 | 1/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.61 |
| ▸ | WNT3A | P56704 | 1/20 | 0.58 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | XIAP | P98170 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2753572 | 0.94 | RORC (0.74) | RORCADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL6276729 | 0.89 | ADORA1 (0.62) | RORCADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL6281978 | 0.88 | ADORA2A (0.64) | RORCADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL6286094 | 0.82 | ALDH1A1 (0.73) | RORCADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL2753574 | 0.79 | RORC (0.65) | RORCADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL974509 | 0.79 | RORC (0.60) | RORCADORA2AADORA1ELOVL1NFKB1 | |
| SCHEMBL13357164 | 0.78 | ALDH1A1 (0.70) | PRKACAROCK1SMN1; SMN2 | |
| SCHEMBL1449648 | 0.78 | ADORA2A (1.00) | RORCADORA2AADORA1NFKB1CSNK1D | |
| SCHEMBL1449625 | 0.78 | ADORA2A (1.00) | RORCADORA2AADORA1 | |
| SCHEMBL7843818 | 0.77 | RORC (0.68) | RORCADORA2AADORA1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6962933-B1 | Method for inhibiting p38 MAP kinase or TNF-α production using a 1,3-thiazole | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-08 | — | — | US | disclosed |
| US-20050080113-A1 | Medicinal compositions | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-04-14 | — | — | US | disclosed |
| US-20040097555-A1 | Concomitant drugs | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-05-20 | — | — | US | disclosed |
| EP-1402900-A1 | MEDICINAL COMPOSITIONS | Takeda Chemical Industries, Ltd. (JP) | 2004-03-31 | — | — | EP | disclosed |
| EP-1354603-A1 | CONCOMITANT DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2003-10-22 | — | — | EP | disclosed |
| EP-1205478-A1 | p38MAP KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2002-05-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080113-A1 | Medicinal compositions | TNF, TRAF6, MMP8 | RORC 609/4885ADORA2A 1487/4885ADORA1 1594/4885 |
| US-20040097555-A1 | Concomitant drugs | TNF, CHUK, CNKSR1 | RORC 226/4885ADORA2A 1689/4885ADORA1 2218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.