SCHEMBL6283992

SCHEMBL6283992

CC(C)(C)c1ccc(C2=Cc3ccccc3C2)cc1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 2/20 0.49
CYP11B2 P19099 2/20 0.49
PTGS2 P35354 3/20 0.45
IP6K1 Q92551 1/20 0.41
IP6K3 Q96PC2 1/20 0.41
CYP19A1 P11511 1/20 0.41
PTAFR P25105 1/20 0.39
TSHR P16473 1/20 0.38
NISCH Q9Y2I1 1/20 0.36
KIF11 P52732 3/20 0.36
FGF23 Q9GZV9 1/20 0.36
DRD2 P14416 1/20 0.35
DRD4 P21917 1/20 0.35
HDAC6 Q9UBN7 1/20 0.34
TNF P01375 1/20 0.34
NOD1 Q9Y239 1/20 0.34
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2627002 0.91 CYP11B1 (0.42) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL29897870 0.85 CYP11B1 (0.47) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL6280690 0.85 CYP11B1 (0.47) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL6285696 0.83 CYP11B1 (0.49) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL30487694 0.82 CYP11B1 (0.54) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL6287169 0.82 CYP11B1 (0.54) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL8058170 0.80 CYP11B2 (0.61) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL6285180 0.80 CYP11B2 (0.61) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL319265 0.79 CYP11B2 (0.65) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL31608568 0.79 CYP11B2 (0.65) CYP11B1CYP11B2PTGS2IP6K1IP6K3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1120182-C Thermoplastic elastic stereoblock olefin polymer, preparation method and metallocene catalyst UNIV LELAND STANFORD JUNIOR (US) 2003-09-03 CN claimed
US-6143842-A CONTINUOUSLY TRANSFERRING POLYOLEFIN, RESIDUAL CATALYST AND UNREACTED MONOMER TO CONDITIONING ZONE OF KNOWN VOLUME AND HEATING; CONTROLLING TRANSFER/REMOVAL OF POLYOLEFIN FROM THE ZONE TO ENABLE MONOMER REMOVAL WITHOUT OVERHEATING POLYOLEFIN HUNTSMAN POLYMERS CORPORATION (US) 2000-11-07 US claimed
US-5594080-A POLYMERIZATION CATALYSIS OF METALLOCENES WITH CYCLOPENTADIENE AND METALS LELAND STANFORD, JR. UNIVERSITY (US) 1997-01-14 US claimed
EP-3148937-B1 METALLIC COMPLEX CATALYST AND POLYMERIZATION METHODS EMPLOYING SAME BRIDGESTONE CORP (JP) 2019-09-18 EP disclosed
CN-106536414-B Metal complex catalyst and polymerization process using the same 株式会社普利司通 2018-12-04 CN disclosed
CN-108884282-A Polyethylene and its formed body 日本聚乙烯株式会社 2018-11-23 CN disclosed
US-10017595-B2 Metallic complex catalyst and polymerization methods employing same BRIDGESTONE CORPORATION (JP) 2018-07-10 US disclosed
US-20170114171-A1 Metallic Complex Catalyst And Polymerization Methods Employing Same BRIDGESTONE CORPORATION (JP) 2017-04-27 US disclosed
EP-3148937-A1 METALLIC COMPLEX CATALYST AND POLYMERIZATION METHODS EMPLOYING SAME Bridgestone Corporation (JP) 2017-04-05 EP disclosed
CN-105358586-A Cyclopropyl substituted metallocene catalysts EXXONMOBIL CHEM PATENTS INC 2016-02-24 CN disclosed
WO-2015183770-A1 METALLIC COMPLEX CATALYST AND POLYMERIZATION METHODS EMPLOYING SAME BRIDGESTONE CORPORATION (JP) 2015-12-03 WO disclosed
WO-1998046547-A1 PROCESS FOR PREPARING 2-ARYL-SUBSTITUTED INDENES MONTELL TECHNOLOGY COMPANY B.V. (NL) 1998-10-22 WO disclosed
EP-0802935-A4 THERMOPLASTIC ELASTOMERIC STEREOBLOCK OLEFIN POLYMERS METHODS AND METALLOCENE CATALYSTS UNIV LELAND STANFORD JUNIOR (US) 1998-09-30 EP disclosed
US-5747621-A CATALYTIC ADDITION POLYMERIZATION MONTELL TECHNOLOGY COMPANY BV (NL) 1998-05-05 US disclosed
CN-1172488-A Thermoplastic elastomeric stereoblock olefin polymers methods and metallocene catalysts TRUSTEES FO THE LELAND STANFOR (US) 1998-02-04 CN disclosed
EP-0802935-A1 THERMOPLASTIC ELASTOMERIC STEREOBLOCK OLEFIN POLYMERS METHODS AND METALLOCENE CATALYSTS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1997-10-29 EP disclosed
US-5594080-A POLYMERIZATION CATALYSIS OF METALLOCENES WITH CYCLOPENTADIENE AND METALS LELAND STANFORD, JR. UNIVERSITY (US) 1997-01-14 US disclosed
EP-0745099-A1 REACTOR BLEND POLYPROPYLENE, PROCESS FOR THE PREPARATION THEREOF AND PROCESS FOR PREPARING METALLOCENE LIGANDS Montell Technology Company bv (NL) 1996-12-04 EP disclosed
WO-1996020225-A2 REACTOR BLEND POLYPROPYLENE, PROCESS FOR THE PREPARATION THEREOF AND PROCESS FOR PREPARING METALLOCENE LIGANDS MONTELL TECHNOLOGY COMPANY B.V. (NL) 1996-07-04 WO disclosed
WO-1995025757-A1 THERMOPLASTIC ELASTOMERIC STEREOBLOCK OLEFIN POLYMERS METHODS AND METALLOCENE CATALYSTS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1995-09-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170114171-A1 Metallic Complex Catalyst And Polymerization Methods Employing Same C5, C1S, C9 CYP11B1 387/4885CYP11B2 322/4885PTGS2 232/4885
US-10017595-B2 Metallic complex catalyst and polymerization methods employing same C5, C1S, C9 CYP11B1 387/4885CYP11B2 322/4885PTGS2 232/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.