SCHEMBL6285696

SCHEMBL6285696

FC(F)(F)c1ccc(C2=Cc3ccccc3C2)cc1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 2/20 0.49
CYP11B2 P19099 2/20 0.49
KIF11 P52732 5/20 0.47
PTGS2 P35354 2/20 0.41
BACE1 P56817 1/20 0.41
IP6K1 Q92551 1/20 0.41
IP6K3 Q96PC2 1/20 0.41
CYP19A1 P11511 1/20 0.41
ALDH1A1 P00352 1/20 0.39
TSHR P16473 1/20 0.39
SCN2A Q99250 2/20 0.36
NISCH Q9Y2I1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6290470 0.85 CYP11B1 (0.47) CYP11B1CYP11B2KIF11PTGS2IP6K1
SCHEMBL6283992 0.83 CYP11B1 (0.49) CYP11B1CYP11B2KIF11PTGS2IP6K1
SCHEMBL6286855 0.80 CYP11B1 (0.53) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL31414397 0.80 CYP11B1 (0.53) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL6285180 0.80 CYP11B2 (0.61) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL8058170 0.80 CYP11B2 (0.61) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL31608568 0.79 CYP11B2 (0.65) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL319265 0.79 CYP11B2 (0.65) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL30487694 0.78 CYP11B1 (0.54) CYP11B1CYP11B2PTGS2IP6K1IP6K3
SCHEMBL6287169 0.78 CYP11B1 (0.54) CYP11B1CYP11B2PTGS2IP6K1IP6K3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101429257-A Modified particle and its manufacturing method, carrier, catalyst component for addition polymerization, catalyst for addition polymerization and manufacturing method of addition polymer SUMITOMO CHEMICAL CO (JP) 2009-05-13 CN disclosed
CN-1693314-A Modified particle, method for producing catalyst component or catalyst for addition polymerization, and method for producing addition polymer SUMITOMO CHEMICAL CO (JP) 2005-11-09 CN disclosed
US-6960550-B2 Catalyst systems for high melting thermoplastic elastomeric α-olefin polymers and plastomers THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2005-11-01 US disclosed
US-20030195308-A1 Catalyst systems for high melting thermoplastic elastomeric alpha-olefin polymers and plastomers THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2003-10-16 US disclosed
EP-0910560-B1 PROCESS FOR PREPARING 2-ARYL-SUBSTITUTED INDENES BASELL POLYOLEFINE GMBH (DE) 2003-09-17 EP disclosed
CN-1120182-C Thermoplastic elastic stereoblock olefin polymer, preparation method and metallocene catalyst UNIV LELAND STANFORD JUNIOR (US) 2003-09-03 CN disclosed
US-6566544-B1 Indene ring-containing metallocene-complex catalysts THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY 2003-05-20 US disclosed
US-6559262-B1 An elastomeric amorphous-crystalline blocks copolymer of at least one alpha olefin monomor with ethylene having less than 10 mole % ethylene units, said ethylene is incorporated randomly between the olefin units in the polymer chain with a THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY 2003-05-06 US disclosed
EP-0991675-A4 ETHYLENE ENHANCEMENT OF PROCESSES FOR SYNTHESIS OF HIGH MELTING THERMOPLASTIC ELASTOMERIC ALPHA-OLEFIN POLYMERS (PRE/EPE EFFECTS) UNIV LELAND STANFORD JUNIOR (US) 2002-07-03 EP disclosed
US-6271411-B1 REACTING AN INDENE WITH AN ARENE COMPOUND SUBSTITUTED WITH AN HALOGEN ATOM, PREFERABLY A IODINE ATOM, OR WITH AN ORGANOSULPHONATE GROUP, IN A BASIC MEDIUM IN THE PRESENCE OF A PALLADIUM CATALYST. MONTELL TECHNOLOGY COMPANY BV (NL) 2001-08-07 US disclosed
EP-0991675-A1 ETHYLENE ENHANCEMENT OF PROCESSES FOR SYNTHESIS OF HIGH MELTING THERMOPLASTIC ELASTOMERIC $g(a)-OLEFIN POLYMERS (PRE/EPE EFFECTS) THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2000-04-12 EP disclosed
US-5969070-A HOMOGENEOUS COMPOSITION FORMED FROM LINEAR OR BRANCHED CHAIN C3 TO C10 MONOMERS SUCH AS PROPYLENE, 1-BUTENE, 1-PENTENE, 4-METHYL-1-PENTENE, 1-HEXENE AND MIXTURES THEREOF, COMPRISING ALTERNATING ISOTACTIC AND ATACTIC DISASTEREOSEQUENCES THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1999-10-19 US disclosed
CN-1228072-A Process for preparing 2-aryl-substituted indenes MONTELL TECHNOLOGY COMPANY BV (NL) 1999-09-08 CN disclosed
EP-0910560-A1 PROCESS FOR PREPARING 2-ARYL-SUBSTITUTED INDENES Montell Technology Company bv (NL) 1999-04-28 EP disclosed
WO-1998057996-A1 ETHYLENE ENHANCEMENT OF PROCESSES FOR SYNTHESIS OF HIGH MELTING THERMOPLASTIC ELASTOMERIC α-OLEFIN POLYMERS (PRE/EPE EFFECTS) THE BOARD OF TRUSTEES OF THE LELAND STANFORD, JR. UNIVERSITY (US) 1998-12-23 WO disclosed
WO-1998046547-A1 PROCESS FOR PREPARING 2-ARYL-SUBSTITUTED INDENES MONTELL TECHNOLOGY COMPANY B.V. (NL) 1998-10-22 WO disclosed
EP-0802935-A4 THERMOPLASTIC ELASTOMERIC STEREOBLOCK OLEFIN POLYMERS METHODS AND METALLOCENE CATALYSTS UNIV LELAND STANFORD JUNIOR (US) 1998-09-30 EP disclosed
CN-1172488-A Thermoplastic elastomeric stereoblock olefin polymers methods and metallocene catalysts TRUSTEES FO THE LELAND STANFOR (US) 1998-02-04 CN disclosed
EP-0802935-A1 THERMOPLASTIC ELASTOMERIC STEREOBLOCK OLEFIN POLYMERS METHODS AND METALLOCENE CATALYSTS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1997-10-29 EP disclosed
WO-1995025757-A1 THERMOPLASTIC ELASTOMERIC STEREOBLOCK OLEFIN POLYMERS METHODS AND METALLOCENE CATALYSTS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1995-09-28 WO disclosed