Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6287411 | 0.78 | MEN1 (0.42) | ACHEBRD4CREBBPALDH1A1DRD2 | |
| SCHEMBL6280465 | 0.77 | ALDH1A1 (0.43) | KDM4EGAAALOX15ACHEGSK3B | |
| SCHEMBL10371860 | 0.76 | TP53 (0.46) | KDM4ETP53GAAALOX15GSK3B | |
| SCHEMBL6284373 | 0.75 | KMT2A (0.48) | KDM4EALDH1A1HSD17B10TSHRRORC | |
| SCHEMBL6289025 | 0.71 | ACHE (0.42) | KDM4EACHEBRD4CREBBPALDH1A1 | |
| SCHEMBL6289026 | 0.71 | ACHE (0.42) | KDM4EACHEBRD4CREBBPALDH1A1 | |
| SCHEMBL14371832 | 0.70 | HTT (0.69) | KDM4ETP53GAAALOX15GSK3B | |
| SCHEMBL6285055 | 0.69 | ACHE (0.40) | KDM4ETP53ALOX15ACHEBRD4 | |
| SCHEMBL6285053 | 0.69 | ACHE (0.40) | KDM4ETP53ALOX15ACHEBRD4 | |
| SCHEMBL6285059 | 0.69 | ACHE (0.40) | KDM4ETP53ALOX15ACHEBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6927294-B1 | Nitrogen-containing heterocycles | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2005-08-09 | — | — | US | disclosed |