Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | TSHR | P16473 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11362721 | 0.91 | NPC1 (0.62) | NPC1POLBSMN1; SMN2RAB9ATSHR | |
| SCHEMBL3375297 | 0.84 | ALDH1A1 (0.77) | NPC1POLBSMN1; SMN2RAB9ATSHR | |
| SCHEMBL29933548 | 0.84 | ALDH1A1 (0.77) | NPC1POLBSMN1; SMN2RAB9ATSHR | |
| SCHEMBL11509288 | 0.82 | MAPT (0.68) | NPC1POLBSMN1; SMN2RAB9ATSHR | |
| SCHEMBL11356469 | 0.81 | NPC1 (0.61) | NPC1POLBSMN1; SMN2RAB9ATSHR | |
| SCHEMBL6720375 | 0.78 | MAOB (0.69) | NPC1SMN1; SMN2RAB9ATSHRLMNA | |
| SCHEMBL29933496 | 0.76 | MAOB (0.56) | NPC1POLBSMN1; SMN2RAB9ATSHR | |
| SCHEMBL10898831 | 0.76 | MAOB (0.56) | NPC1POLBSMN1; SMN2RAB9ATSHR | |
| SCHEMBL14541242 | 0.75 | CA12 (0.58) | NPC1POLBSMN1; SMN2RAB9ATSHR | |
| SCHEMBL4130899 | 0.75 | ALDH1A1 (1.00) | NPC1POLBSMN1; SMN2RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6933317-B2 | PGD2 receptor antagonistic pharmaceutical compositions | SHIONOGI & CO. LTD. (JP) | 2005-08-23 | — | — | US | disclosed |
| US-20040054003-A1 | Pgd2 receptor antagonistic pharmaceutical compositions | SHIONGI & CO., LTD. (JP) | 2004-03-18 | — | — | US | disclosed |
| EP-1338594-A1 | PGD2 RECEPTOR ANTAGONISTIC PHARMACEUTICAL COMPOSITIONS | SHIONOGI & CO., LTD. (JP) | 2003-08-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040054003-A1 | Pgd2 receptor antagonistic pharmaceutical compositions | PTGDR, PTGDR2, HRH2 | NPC1 1271/4885POLB 3557/4885SMN1; SMN2 4355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.