Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6260311 | 1.00 | TSHR (0.42) | TSHRGABRA1GABRG2GABRB3GABRA5 | |
| Piperazine SCHEMBL27593726 | 0.89 | GABRA1 (0.36) | TSHRGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL9081705 | 0.83 | CA2 (0.50) | TSHRCA2TDP1 | |
| Piperazine SCHEMBL5875243 | 0.79 | TSHR (0.50) | TSHRGABRA1GABRG2GABRB3GABRA5 | |
| Piperazine SCHEMBL2445779 | 0.79 | TSHR (0.50) | TSHRGABRA1GABRG2GABRB3GABRA5 | |
| Sulfuric Acid SCHEMBL6099992 | 0.79 | TSHR (0.50) | TSHRGABRA1GABRG2GABRB3GABRA5 | |
| Sulfuric Acid SCHEMBL6099988 | 0.79 | TSHR (0.50) | TSHRGABRA1GABRG2GABRB3GABRA5 | |
| Sulfuric Acid SCHEMBL8291975 | 0.79 | TSHR (0.50) | TSHRGABRA1GABRG2GABRB3GABRA5 | |
| Sulfuric Acid SCHEMBL8300104 | 0.79 | TSHR (0.50) | TSHRGABRA1GABRG2GABRB3GABRA5 | |
| Piperazine SCHEMBL27978492 | 0.79 | TSHR (0.50) | TSHRGABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1721493-A | Multiple process polishing solution for chemical mechanical planarization | ROHM & HAAS ELECT MAT (US) | 2006-01-18 | — | — | CN | claimed |
| US-6971945-B2 | Multi-step polishing solution for chemical mechanical planarization | ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. (US) | 2005-12-06 | — | — | US | claimed |
| US-20050194357-A1 | MULTI-STEP POLISHING SOLUTION FOR CHEMICAL MECHANICAL PLANARIZATION | ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. | 2005-09-08 | — | — | US | claimed |
| CN-111771885-A | Pest control composition comprising novel iminopyridine derivatives | 明治制果药业株式会社 | 2020-10-16 | — | — | CN | disclosed |
| CN-108069923-A | A kind of piperazines compound ion liquid, preparation method and its application in aramid fiber 1313 is dissolved | 浙江蓝德能源科技发展有限公司 | 2018-05-25 | — | — | CN | disclosed |
| CN-103945842-A | Methods of treating intrapulmonary infections | CUBIST PHARM INC | 2014-07-23 | — | — | CN | disclosed |
| CN-1324105-C | Multiple process polishing solution for chemical mechanical planarization | CMP ROHM & HAAS ELECTRONIC MAT (US) | 2007-07-04 | — | — | CN | disclosed |
| CN-1721493-A | Multiple process polishing solution for chemical mechanical planarization | ROHM & HAAS ELECT MAT (US) | 2006-01-18 | — | — | CN | disclosed |
| US-6971945-B2 | Multi-step polishing solution for chemical mechanical planarization | ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. (US) | 2005-12-06 | — | — | US | disclosed |
| US-20050194357-A1 | MULTI-STEP POLISHING SOLUTION FOR CHEMICAL MECHANICAL PLANARIZATION | ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. | 2005-09-08 | — | — | US | disclosed |