Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11391249 | 0.86 | POLB (0.49) | MAPK9L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL6285208 | 0.76 | KDM4E (0.46) | HTTMAPK9MAPK10L3MBTL1KDM4E | |
| SCHEMBL23176173 | 0.73 | SMN1; SMN2 (0.40) | KDM4EALDH1A1ADORA2APOLBLMNA | |
| SCHEMBL6286431 | 0.73 | MAPK9 (0.42) | MAPK9MAPK10L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL11386388 | 0.71 | KDM4E (0.54) | KDM4EALDH1A1CYP1A2HPGDPOLB | |
| SCHEMBL23143395 | 0.68 | KDR (0.42) | HTTMAPK9MAPK10ADORA2AMAPT | |
| SCHEMBL23331067 | 0.67 | TOP2A (0.35) | ALDH1A1EEDSMN1; SMN2MAPK1 | |
| SCHEMBL2451213 | 0.66 | L3MBTL1 (0.49) | MAPK9MAPK10L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL25169867 | 0.66 | ABL1 (0.54) | HTTL3MBTL1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL21672427 | 0.66 | SMN1; SMN2 (0.33) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921762-B2 | Substituted indolizine-like compounds and methods of use | AMGEN INC. (US) | 2005-07-26 | — | — | US | disclosed |