Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29611794 | 0.86 | CD274 (0.39) | AURKAKDRCDK2CA1CA2 | |
| SCHEMBL4602986 | 0.83 | AURKA (0.41) | AURKAKDRCDK2ALDH1A1HTT | |
| SCHEMBL30390867 | 0.83 | AURKA (0.41) | AURKAKDRCDK2ALDH1A1HTT | |
| SCHEMBL5851492 | 0.82 | KDR (0.49) | AURKAKDRCDK2CA1CA2 | |
| SCHEMBL28796136 | 0.80 | IDO1 (0.45) | AURKAKDRCDK2ALDH1A1HTT | |
| SCHEMBL12666357 | 0.76 | CDK2 (0.39) | AURKAKDRCDK2CYP1A2CYP2A6 | |
| SCHEMBL15416944 | 0.76 | CDK2 (0.47) | AURKAKDRCDK2ATMALDH1A1 | |
| SCHEMBL15416821 | 0.74 | KDR (0.47) | AURKAKDRCDK2ATMDAO | |
| SCHEMBL218508 | 0.74 | TRPA1 (0.52) | TRPA1ATMALDH1A1CA1CA2 | |
| SCHEMBL30834716 | 0.74 | TRPA1 (0.52) | TRPA1ATMALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967242-B2 | Antimicrobial 2-deoxystreptamine compounds | ISIS PHARMACEUTICALS, INC. (US) | 2005-11-22 | — | — | US | claimed |
| US-6759523-B2 | ANALOGS OF AMINOGLYCOSIDE COMPOUNDS OF THE CLASS HAVING A GLYCOSYLATED 2-DEOXYSTREPTAMINE RING; BINDING AFFINITY FOR THE A SITE OF BACTERIAL 16S RIBOSOMAL RNA | ISIS PHARMACEUTICALS, INC. | 2004-07-06 | — | — | US | claimed |
| US-20030109461-A1 | Antimicrobial 2-deoxystreptamine compounds | ISIS PHARMACEUTICALS, INC. | 2003-06-12 | — | — | US | claimed |
| US-20020052526-A1 | Antimicrobial 2-deoxystreptamine compounds | ISIS PHARMACEUTICAL, INC. | 2002-05-02 | — | — | US | claimed |
| WO-2001039726-A2 | ANTIMICROBIAL 2-DEOXYSTREPTAMINE COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2001-06-07 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030109461-A1 | Antimicrobial 2-deoxystreptamine compounds | DUT, GNE, ST6GAL1 | AURKA 3288/4885KDR 4037/4885CDK2 2375/4885 |
| US-20020052526-A1 | Antimicrobial 2-deoxystreptamine compounds | DUT, GNE, ST6GAL1 | AURKA 3288/4885KDR 4037/4885CDK2 2375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.