Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 4/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.48 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.48 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5166497 | 0.91 | NR1H4 (0.48) | NR1H4ATMTUBB4ATUBBTUBA3C | |
| SCHEMBL6285249 | 0.87 | NR1H4 (0.63) | NR1H4ATMKDM4EGAAMAPT | |
| SCHEMBL5373182 | 0.80 | NR1H4 (0.63) | NR1H4ATMTUBB4ATUBBTUBA3C | |
| SCHEMBL5165916 | 0.77 | ALOX5 (0.54) | NR1H4ATMKDM4EALDH1A1GAA | |
| SCHEMBL5425036 | 0.77 | NR1H4 (0.62) | NR1H4ATMTUBB4ATUBBTUBA3C | |
| SCHEMBL5166471 | 0.73 | GAA (0.61) | NR1H4ATMTUBB4ATUBBTUBA3C | |
| SCHEMBL5168318 | 0.73 | MAPT (0.64) | NR1H4TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5374835 | 0.72 | MAPT (0.80) | NR1H4TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6285265 | 0.70 | NR1H4 (0.48) | NR1H4ATMALOX5 | |
| SCHEMBL5164965 | 0.70 | GAA (0.56) | NR1H4ATMKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849642-B2 | Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring | GRUENENTHAL GMBH (DE) | 2005-02-01 | — | — | US | claimed |
| EP-1218380-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | GRUENENTHAL GMBH (DE) | 2003-12-17 | — | — | EP | claimed |
| US-20020183327-A1 | Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring | GRUENENTHAL GMBH. | 2002-12-05 | — | — | US | claimed |
| US-6849642-B2 | Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring | GRUENENTHAL GMBH (DE) | 2005-02-01 | — | — | US | disclosed |
| EP-1218380-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | GRUENENTHAL GMBH (DE) | 2003-12-17 | — | — | EP | disclosed |
| US-20020183327-A1 | Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring | GRUENENTHAL GMBH. | 2002-12-05 | — | — | US | disclosed |
| EP-1218380-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | Grünenthal GmbH (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001027110-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183327-A1 | Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring | OPRK1, GRIN3A, OPRM1 | NR1H4 451/4885ATM 4457/4885TUBB4A 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.