Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL707002 | 0.84 | SIGMAR1 (0.43) | NR4A2SIGMAR1BCHEACHE | |
| SCHEMBL7816473 | 0.80 | NR4A2 (0.47) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL774724 | 0.74 | GABRA1 (0.41) | NR4A2SIGMAR1GABRA1GABRB1GABRA3 | |
| SCHEMBL774723 | 0.73 | NR4A2 (0.43) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL16920143 | 0.72 | NR4A2 (0.61) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL2296301 | 0.69 | CHRM2 (0.49) | GABRA1GABRB2 | |
| SCHEMBL2296295 | 0.69 | CHRM2 (0.49) | GABRA1GABRB2 | |
| SCHEMBL3130492 | 0.68 | NR4A2 (0.55) | NR4A2SIGMAR1GABRA1GABRB1GABRA3 | |
| SCHEMBL17417676 | 0.68 | CYP2C19 (0.65) | — | |
| SCHEMBL9340439 | 0.68 | ALDH1A1 (0.71) | NR4A2GABRA1GABRB1GABRA3GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6914145-B2 | Acylation process | PFIZER, INC. (US) | 2005-07-05 | — | — | US | disclosed |
| US-20020188138-A1 | Acylation process | PFIZER INC. | 2002-12-12 | — | — | US | disclosed |
| US-6441192-B1 | ADDING ACID CHLORIDE AND ALKYL OR ARYL MAGNESIUM HALIDE SEPARATELY AND SIMULTANEOUSLY TO A STIRRED SOLUTION OF AN INDOLE SUCH THAT THE TWO REAGENTS DO NOT COME INTO IMMEDIATE CONTACT; SYNCHRONISED RATES OF MOLAR ADDITION | PFIZER INC. | 2002-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020188138-A1 | Acylation process | IDO1, IDO2, AANAT | NR4A2 3114/4885SIGMAR1 2839/4885GABRA1 1306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.