Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | KLK1 | P06870 | 4/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.36 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 2/20 | 0.34 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7039294 | 0.88 | KLK1 (0.39) | KLK1KLK5MEN1KMT2ANPC1 | |
| Trifluoroacetic Acid SCHEMBL6287884 | 0.86 | KEAP1 (0.37) | KLK1KLK5MEN1KMT2ANPC1 | |
| Trifluoroacetic Acid SCHEMBL6290918 | 0.86 | MLYCD (0.37) | KLK1KLK5MEN1KMT2ANPC1 | |
| Trifluoroacetic Acid SCHEMBL6287794 | 0.86 | MLYCD (0.37) | KLK1KLK5MEN1KMT2ANPC1 | |
| Trifluoroacetic Acid SCHEMBL7039259 | 0.84 | GABRB1 (0.40) | NR1H4DEGS1MEN1KMT2ANPC1 | |
| Trifluoroacetic Acid SCHEMBL7038495 | 0.83 | TP53 (0.35) | KLK1KLK5NPC1RAB9AF2 | |
| SCHEMBL6290435 | 0.81 | EGFR (0.34) | KLK1DEGS1PLGKLK6 | |
| SCHEMBL6290421 | 0.81 | EGFR (0.34) | KLK1DEGS1PLGKLK6 | |
| Trifluoroacetic Acid SCHEMBL6288018 | 0.80 | CES1 (0.39) | NPC1RAB9ACA12CA2CA9 | |
| Trifluoroacetic Acid SCHEMBL6286281 | 0.80 | CES1 (0.39) | NPC1RAB9ACA12CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887890-B2 | Compounds exhibiting thrombopoietin-like activities | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-05-03 | — | — | US | disclosed |
| US-20030162724-A1 | Compounds exhibiting thrombopoietin-like activities | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-08-28 | — | — | US | disclosed |
| EP-1291341-A1 | COMPOUNDS EXHIBITING THROMBOPOIETIN-LIKE ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162724-A1 | Compounds exhibiting thrombopoietin-like activities | MPL, THPO, TEK | NR1H4 3735/4885KLK1 2324/4885KLK5 3413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.