Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288516 | 0.82 | S1PR2 (0.39) | ALDH1A1ALDH1A2ALDH1A3MAPTHSD17B10 | |
| SCHEMBL4772359 | 0.68 | KDM4E (0.45) | SMN1; SMN2ALDH1A1MAPTMAPK1HSD17B10 | |
| SCHEMBL16505555 | 0.65 | NPC1 (0.48) | ALDH1A1MAPTMAPK1PTGESHSD17B10 | |
| SCHEMBL6701828 | 0.65 | KDM4E (0.49) | SMN1; SMN2ALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL6288769 | 0.63 | MAPT (0.39) | SMN1; SMN2ALDH1A1MAPTHSD17B10S1PR2 | |
| SCHEMBL6290563 | 0.63 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1MAPTMAPK1HSD17B10 | |
| SCHEMBL4770110 | 0.63 | LMNA (0.53) | SMN1; SMN2ALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL4772765 | 0.63 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL4778595 | 0.61 | PDE4B (0.44) | SMN1; SMN2ALDH1A1MAPTMAPK1HSD17B10 | |
| SCHEMBL4771734 | 0.61 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1MAPTHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900223-B2 | Dihydrodipyrazolopyridinone inhibitors of B7-1 | WYETH (US) | 2005-05-31 | — | — | US | disclosed |
| US-20040044024-A1 | Dihydrodipyrazolopyridinone inhibitors of B7-1 | WYETH (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044024-A1 | Dihydrodipyrazolopyridinone inhibitors of B7-1 | CD274, PDCD1, PDCD1LG2 | SMN1; SMN2 3581/4885ALDH1A1 53/4885ALDH1A2 465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.