Formononetin

Formononetin

SCHEMBL62915

COc1ccc(-c2coc3cc(O)ccc3c2=O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 1.00
ALDH1A1 P00352 8/20 1.00
SMN1; SMN2 Q16637 8/20 1.00
HSD17B10 Q99714 7/20 1.00
HPGD P15428 7/20 1.00
MAPT P10636 6/20 1.00
CYP3A4 P08684 6/20 1.00
MAOA P21397 6/20 1.00
MAOB P27338 6/20 1.00
TP53 P04637 5/20 1.00
CYP2D6 P10635 4/20 1.00
CYP2C9 P11712 4/20 1.00
CYP2C19 P33261 4/20 1.00
MEN1 O00255 4/20 1.00
KMT2A Q03164 4/20 1.00
HDAC6 Q9UBN7 2/20 1.00
CYP1B1 Q16678 2/20 1.00
BCL2 P10415 1/20 1.00
IL2 P60568 1/20 1.00
XDH P47989 2/20 0.85

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Formononetin SCHEMBL15271536 1.00 KDM4E (1.00) KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD
Formononetin SCHEMBL29361145 1.00 KDM4E (1.00) KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD
Formononetin SCHEMBL8416577 0.99 KDM4E (0.97) KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD
Formononetin SCHEMBL6638953 0.99 KDM4E (0.97) KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD
SCHEMBL4175335 0.93 KDM4E (0.86) KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD
Isoformonentin SCHEMBL73338 0.92 XDH (1.00) KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD
Isoformonentin SCHEMBL30105310 0.92 XDH (1.00) KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD
Formononetin SCHEMBL247496 0.92 KDM4E (0.84) KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD
Glycitein SCHEMBL6578666 0.90 RAB9A (0.85) KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD
Formononetin SCHEMBL4223418 0.90 MAPT (0.83) KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 9744 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116850183-B Methods and pharmaceutical compositions for treating myopia GRAND PHARMA (CHINA) Co.,Ltd. (CN) 2026-05-26 CN claimed
CN-117327135-B Method for increasing leaching of saccharides and glycoside components and application thereof INSTITUTE OF CHINESE MATERIA MEDICA, CHINA ACADEMY OF CHINESE MEDICAL SCIENCES (CN) 2026-05-26 CN claimed
CN-120989051-B Beta-1, 6-glycosidic bond hydrolase and application thereof in traditional Chinese medicine resource 南京中医药大学 2026-05-19 CN claimed
CN-122067647-A Prediction and depth verification integration method for traditional Chinese medicine compound action mechanism research 国药集团德众(佛山)药业有限公司 2026-05-19 CN claimed
CN-122063217-A Quality transmission quality control method for whole preparation process of qi-tonifying, nerve-soothing and mass-eliminating mixture 江苏省中医院 2026-05-19 CN claimed
CN-122056908-A Application of formononetin in preparing medicine for regulating BNIP3 mediated excessive autophagy of mitochondria 中国人民解放军军事科学院军事医学研究院 2026-05-19 CN claimed
CN-122031598-A Preparation method and application of nephritis medicine 五源本草(山东)健康科技有限公司 2026-05-15 CN claimed
US-20260130395-A1 Water Dispersible Botanical Compositions AQUILA BLACK LTD (AU) 2026-05-14 US claimed
CN-122005513-A Anti-tumor and/or anti-iron death small molecule composition and application thereof 北京慧宝源生物技术股份有限公司 2026-05-12 CN claimed
US-20260103663-A1 ANTIMICROBIAL MATERIALS AND NANOPARTICLES AND METHODS OF USE THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2026-04-16 US claimed
WO-1994023716-A1 METHOD FOR TREATMENT OF MENOPAUSAL AND PREMENSTRUAL SYMPTOMS TUFTS UNIVERSITY SCHOOL OF MEDICINE (US) 1994-10-27 WO claimed
WO-1993023069-A1 HEALTH SUPPLEMENTS CONTAINING PHYTO-OESTROGENS, ANALOGUES OR METABOLITES THEREOF KELLY GRAHAM EDMUND (AU) 1993-11-25 WO claimed
US-5229113-A Gene expression, soybeans LUBRIZOL GENETICS, INC. (US) 1993-07-20 US claimed
EP-0456808-A4 METHOD AND COMPOSITIONS FOR STIMULATING VESICULAR-ARBUSCULAR MYCORRHIZAL FUNGI UNIV MICHIGAN STATE (US) 1992-11-04 EP claimed
US-5125955-A Plant safening agents and growth regulators BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) 1992-06-30 US claimed
US-5085682-A Method and compositions for stimulating vesticular-arbuscular mycorrhizal fungi using isoflavonoids BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) 1992-02-04 US claimed
EP-0456808-A1 METHOD AND COMPOSITIONS FOR STIMULATING VESICULAR-ARBUSCULAR MYCORRHIZAL FUNGI. UNIV MICHIGAN STATE (US) 1991-11-21 EP claimed
CN-1052329-A Methods and compositions for stimulating vesicular-arbuscular mycorrhizal fungi UNIV MICHIGAN STATE (US) 1991-06-19 CN claimed
WO-1991007868-A1 METHOD AND COMPOSITIONS FOR STIMULATING VESICULAR-ARBUSCULAR MYCORRHIZAL FUNGI MICHIGAN STATE UNIVERSITY (US) 1991-06-13 WO claimed
US-5002603-A Stimulating plant growth with isoflavonoid BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) 1991-03-26 US claimed