Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SDHB | P21912 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.41 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | CLPP | Q16740 | 1/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288671 | 0.81 | L3MBTL1 (0.46) | L3MBTL1SDHBCREBBPADORA2AGRIN1 | |
| SCHEMBL6243270 | 0.79 | CYP19A1 (0.44) | L3MBTL1CREBBPADORA2AYTHDC1CYP19A1 | |
| SCHEMBL6288453 | 0.73 | L3MBTL1 (0.49) | L3MBTL1SDHBCREBBPADORA2AADRA1D | |
| SCHEMBL25853598 | 0.73 | L3MBTL1 (0.53) | L3MBTL1SDHBCREBBPADORA2ACYP19A1 | |
| SCHEMBL10080865 | 0.70 | L3MBTL1 (0.56) | L3MBTL1SDHBCREBBPADORA2AGRIN1 | |
| SCHEMBL7359634 | 0.69 | L3MBTL1 (0.57) | L3MBTL1CREBBPADORA2AYTHDC1CYP19A1 | |
| SCHEMBL6288640 | 0.68 | MAPK10 (0.38) | P2RX7 | |
| SCHEMBL434883 | 0.68 | L3MBTL1 (0.53) | L3MBTL1CREBBPADORA2ACYP19A1CYP11B1 | |
| SCHEMBL27383589 | 0.68 | IDH1 (0.54) | L3MBTL1CREBBPADORA2ACYP19A1CYP11B1 | |
| SCHEMBL15504995 | 0.68 | L3MBTL1 (0.56) | L3MBTL1SDHBCREBBPADORA2ACYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6974822-B2 | 3-isoquinolinone derivatives as matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2005-12-13 | — | — | US | disclosed |
| US-20040038959-A1 | 3-Isoquinolinone derivatives as matrix metalloproteinase inhibitors | BUNKER AMY MAE (US) | 2004-02-26 | — | — | US | disclosed |
| WO-2004014378-A1 | 3-ISOQUINOLINONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038959-A1 | 3-Isoquinolinone derivatives as matrix metalloproteinase inhibitors | MMP1, MMP9, MMP3 | L3MBTL1 3891/4885SDHB 3814/4885CREBBP 4303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.