Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1570351 | 0.79 | NPSR1 (0.47) | GAAALDH1A1POLBNPSR1BRD4 | |
| SCHEMBL7000224 | 0.78 | CA2 (0.51) | GAAALDH1A1MMP3MMP8LMNA | |
| SCHEMBL7050294 | 0.73 | ADAMTS4 (0.40) | ALDH1A1MMP3NPSR1SMN1; SMN2 | |
| SCHEMBL3971060 | 0.70 | SMN1; SMN2 (0.37) | ALDH1A1MMP3NPSR1SMN1; SMN2 | |
| SCHEMBL3327270 | 0.70 | LMNA (0.42) | GAAALDH1A1TP53POLBLMNA | |
| SCHEMBL3974092 | 0.67 | SMN1; SMN2 (0.41) | ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL28001091 | 0.67 | GAA (0.45) | GAAALDH1A1POLBLMNAMAPT | |
| SCHEMBL6291993 | 0.66 | SIGMAR1 (0.68) | GAATP53LMNAMAPTSMN1; SMN2 | |
| SCHEMBL28001099 | 0.66 | SMN1; SMN2 (0.50) | ALDH1A1POLBLMNAHTTSMN1; SMN2 | |
| SCHEMBL167548 | 0.66 | SMN1; SMN2 (0.58) | GAAALDH1A1LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855719-B1 | Imidazo[1,2-A]pyridine and pyrazolo[2,3-A]pyridine derivatives | ASTRAZENECA AB (SE) | 2005-02-15 | — | — | US | disclosed |
| EP-1214318-B1 | IMIDAZO[1,2-A]PYRIDINE AND PYRAZOLO[2,3-A]PYRIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-10-08 | — | — | EP | disclosed |