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SCHEMBL6294666

SCHEMBL6294666

CC(C)(C)OC(=O)N1CCc2nc(-c3ccccc3)ncc2C1

nearest known ligand 0.62

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.62
▸ CKS1B P61024 2/20 0.49
▸ SKP1 P63208 2/20 0.49
▸ SKP2 Q13309 2/20 0.49
▸ HPGDS O60760 3/20 0.48
▸ PDE10A Q9Y233 1/20 0.48
▸ ESR2 Q92731 1/20 0.47
▸ MAPK1 P28482 1/20 0.46
▸ NR1H2 P55055 1/20 0.46
▸ UCHL1 P09936 1/20 0.46
▸ ENPP2 Q13822 1/20 0.45
▸ PDGFRB P09619 2/20 0.43
▸ KDR P35968 1/20 0.43
▸ GBA1 P04062 1/20 0.43
▸ NAMPT P43490 1/20 0.43
▸ USP30 Q70CQ3 1/20 0.43
▸ TNKS2 Q9H2K2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30785603 1.00 MAPT (0.62) MAPTCKS1BSKP1SKP2HPGDS
SCHEMBL18563793 0.92 MAPT (0.56) MAPTCKS1BSKP1SKP2HPGDS
SCHEMBL21042225 0.91 MAPT (0.52) MAPTCKS1BSKP1SKP2HPGDS
SCHEMBL1014594 0.90 MAPT (0.59) MAPTPDE10AESR2MAPK1NR1H2
SCHEMBL12706798 0.90 MAPT (0.59) MAPTPDE10AESR2MAPK1NR1H2
SCHEMBL16836075 0.89 MAPT (0.58) MAPTPDE10AESR2MAPK1NR1H2
SCHEMBL18550482 0.88 MAPT (0.54) MAPTPDE10AMAPK1
SCHEMBL18563783 0.88 MAPT (0.53) MAPTCKS1BSKP1SKP2HPGDS
SCHEMBL16836112 0.88 MAPT (0.57) MAPTPDE10AESR2MAPK1NR1H2
SCHEMBL18549910 0.87 MAPT (0.56) MAPTPDE10AESR2MAPK1NR1H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10227362-B2 Anti-pulmonary tuberculosis nitroimidazole derivative MEDSHINE DISCOVERY INC. (CN) 2019-03-12 — — US disclosed
US-10227362-B2 Anti-pulmonary tuberculosis nitroimidazole derivative MEDSHINE DISCOVERY INC. (CN) 2019-03-12 — — US disclosed
US-10000484-B2 Inhibitors of the renal outer medullary potassim channel MERCK SHARP & DOHME CORP. (US) 2018-06-19 — — US disclosed
US-10000484-B2 Inhibitors of the renal outer medullary potassim channel MERCK SHARP & DOHME CORP. (US) 2018-06-19 — — US disclosed
US-20180162878-A1 ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE MEDSHINE DISCOVERY INC. (CN) 2018-06-14 — — US disclosed
US-20180162878-A1 ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE MEDSHINE DISCOVERY INC. (CN) 2018-06-14 — — US disclosed
US-20180162878-A1 ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE MEDSHINE DISCOVERY INC. (CN) 2018-06-14 — — US disclosed
EP-3252059-A1 ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE Medshine Discovery Inc. (CN) 2017-12-06 — — EP disclosed
EP-3252059-A1 ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE Medshine Discovery Inc. (CN) 2017-12-06 — — EP disclosed
US-20160304515-A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIM CHANNEL MERCK SHARP & DOHME LLC 2016-10-20 — — US disclosed
US-6936600-B2 Sorbitol dehrydrogenase inhibitors PFIZER INC (US) 2005-08-30 — — US disclosed
US-6869943-B2 Sorbitol dehydrogenase inhibitors PFIZER INC (US) 2005-03-22 — — US disclosed
US-20050020578-A1 Sorbitol dehydrogenase inhibitors PFIZER INC. 2005-01-27 — — US disclosed
US-20040077671-A1 Sorbitol dehydrogenase inhibitors CHU-MOYER MARGARET Y (US) 2004-04-22 — — US disclosed
US-6660740-B1 Sorbitol dehydrogenase inhibitors PFIZER INC 2003-12-09 — — US disclosed
US-6602875-B2 Sorbitol dehydrogenase inhibitors PFIZER INC 2003-08-05 — — US disclosed
US-20030065179-A1 Sorbitol dehydrogenase inhibitors CHU-MOYER MARGARET Y (US) 2003-04-03 — — US disclosed
US-6414149-B1 TREATING DIABETES, TREATING OR PREVENTING DIABETIC COMPLICATIONS PFIZER INC. 2002-07-02 — — US disclosed
EP-1185275-A1 AMINOPYRIMIDINES AS SORBITOL DEHYDROGENASE INHIBITORS Pfizer Products Inc. (US) 2002-03-13 — — EP disclosed
WO-2000059510-A1 AMINOPYRIMIDINES AS SORBITOL DEHYDROGENASE INHIBITORS PFIZER PRODUCTS INC. (US) 2000-10-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050020578-A1 Sorbitol dehydrogenase inhibitors SLC5A1, SORD, SLC5A2 MAPT 2491/4885CKS1B 2705/4885SKP1 1128/4885
US-10000484-B2 Inhibitors of the renal outer medullary potassim channel KCNJ11, KCNJ1, KCNJ2 MAPT 4576/4885CKS1B 1975/4885SKP1 1049/4885
US-20180162878-A1 ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE NDUFV1, NDUFV2, MT-ND4 MAPT 2387/4885CKS1B 3642/4885SKP1 4364/4885
US-20160304515-A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIM CHANNEL KCNJ11, KCNJ1, KCNJ2 MAPT 4576/4885CKS1B 1975/4885SKP1 1049/4885
US-20040077671-A1 Sorbitol dehydrogenase inhibitors SLC5A1, SORD, SLC5A2 MAPT 2399/4885CKS1B 2826/4885SKP1 802/4885
US-20030065179-A1 Sorbitol dehydrogenase inhibitors SLC5A1, SORD, SLC5A2 MAPT 2399/4885CKS1B 2826/4885SKP1 802/4885
US-10227362-B2 Anti-pulmonary tuberculosis nitroimidazole derivative NDUFV1, NDUFV2, MT-ND4 MAPT 2387/4885CKS1B 3642/4885SKP1 4364/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.