Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 6/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 6/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL629545 | 1.00 | ALDH1A1 (0.57) | ALDH1A1MAPTHPGDHTTGAA | |
| SCHEMBL1058879 | 0.84 | ALDH1A1 (0.49) | ALDH1A1MAPTHPGDHTTGAA | |
| SCHEMBL1058878 | 0.84 | ALDH1A1 (0.49) | ALDH1A1MAPTHPGDHTTGAA | |
| SCHEMBL15563222 | 0.82 | ALDH1A1 (0.58) | ALDH1A1MAPTHPGDHTTGAA | |
| SCHEMBL15563223 | 0.82 | ALDH1A1 (0.58) | ALDH1A1MAPTHPGDHTTGAA | |
| SCHEMBL3310563 | 0.82 | NFE2L2 (0.53) | ALDH1A1MAPTHTTGAANPC1 | |
| SCHEMBL2232374 | 0.82 | NFE2L2 (0.53) | ALDH1A1MAPTHTTGAANPC1 | |
| SCHEMBL2232370 | 0.82 | NFE2L2 (0.53) | ALDH1A1MAPTHTTGAANPC1 | |
| SCHEMBL2239090 | 0.81 | POLB (0.46) | ALDH1A1MAPTHPGDHTTGAA | |
| SCHEMBL2239088 | 0.81 | POLB (0.46) | ALDH1A1MAPTHPGDHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534680-B1 | PRENYLATION INHIBITORS AND METHODS OF THEIR SYNTHESIS AND USE | PHARMACO INVESTMENTS INC (US) | 2012-02-22 | — | — | EP | disclosed |
| WO-2011092505-A1 | S100 PROTEIN BINDING INTERACTION INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-08-04 | — | — | WO | disclosed |
| US-7501444-B2 | Prenylation inhibitors and methods of their synthesis and use | PPD DISCOVERY, INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501446-B2 | Prenylation inhibitors and methods of their synthesis and use | PPD DISCOVERY, INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-20080119524-A1 | PRENYLATION INHIBITORS CONTAINING DIMETHYLCYCLOBUTANE AND METHODS OF THEIR SYNTHESIS AND USE | PHARMACEUTICAL PRODUCT DEVELOPMENT, INC. | 2008-05-22 | — | — | US | disclosed |
| US-20070149549-A1 | 3-(Pyrid-3-yl)-5-(thiophen-2-yl)-pyrazoles; prenyl-protein transferase inhibitors | PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC | 2007-06-28 | — | — | US | disclosed |
| US-7166619-B2 | Prenylation inhibitors and methods of their synthesis and use | PPD DISCOVERY , INC. (US) | 2007-01-23 | — | — | US | disclosed |
| US-20070010561-A1 | PRENYLATION INHIBITORS AND METHODS OF THEIR SYNTHESIS AND USE | PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC | 2007-01-11 | — | — | US | disclosed |
| EP-1534279-A4 | PRENYLATION INHIBITORS CONTAINING DIMETHYL-CYCLOBUTANE AND METHODS OF THEIR SYNTHESIS AND USE | PPD DISCOVERY INC (US) | 2006-11-08 | — | — | EP | disclosed |
| US-7112596-B2 | Prenylation inhibitors and methods of their synthesis and use | PPD DISCOVERY, INC. (US) | 2006-09-26 | — | — | US | disclosed |
| US-20060025454-A1 | Prenylation inhibitors and methods of their synthesis and use | PPD DISCOVERY, INC. (US) | 2006-02-02 | — | — | US | disclosed |
| US-6960603-B2 | Prenylation inhibitors and methods of their synthesis and use | PPD DISCOVERY, INC. (US) | 2005-11-01 | — | — | US | disclosed |
| EP-1534279-A2 | PRENYLATION INHIBITORS CONTAINING DIMETHYL-CYCLOBUTANE AND METHODS OF THEIR SYNTHESIS AND USE | PPD DISCOVERY, INC. (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1534680-A1 | PRENYLATION INHIBITORS AND METHODS OF THEIR SYNTHESIS AND USE | PPD DISCOVERY, INC. (US) | 2005-06-01 | — | — | EP | disclosed |
| US-20050004122-A1 | Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use | DEVELOPMENT PARTNERS, LLC | 2005-01-06 | — | — | US | disclosed |
| US-20040116425-A1 | Prenylation inhibitors and methods of their synthesis and use | X-CHEM, INC. | 2004-06-17 | — | — | US | disclosed |
| US-20040053970-A1 | Prenylation inhibitors and methods of their synthesis and use | PPD DISCOVERY, INC. | 2004-03-18 | — | — | US | disclosed |
| WO-2004016741-A2 | PRENYLATION INHIBITORS CONTAINING DIMETHYL-CYCLOBUTANE AND METHODS OF THEIR SYNTHESIS AND USE | PPD DISCOVERY, INC. (US) | 2004-02-26 | — | — | WO | disclosed |
| WO-2004016592-A1 | PRENYLATION INHIBITORS AND METHODS OF THEIR SYNTHESIS AND USE | PPD DISCOVERY, INC. (US) | 2004-02-26 | — | — | WO | disclosed |
| US-6649638-B1 | 5-Pyridin-3-yl-1H-pyrazole-3-carboxylic amide derivatives; cancer, restenosis, psoriasis, endometriosis, atherosclerosis, viral or yeast infection, and corneal neovascularization treatment | PPD DISCOVERY, INC. | 2003-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004122-A1 | Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use | RCE1, GGPS1, FNTA | ALDH1A1 3846/4885MAPT 3212/4885HPGD 853/4885 |
| US-20060025454-A1 | Prenylation inhibitors and methods of their synthesis and use | FNTA, RCE1, GGPS1 | ALDH1A1 3638/4885MAPT 3074/4885HPGD 712/4885 |
| US-20070149549-A1 | 3-(Pyrid-3-yl)-5-(thiophen-2-yl)-pyrazoles; prenyl-protein transferase inhibitors | FNTA, PTAR1, ZMPSTE24 | ALDH1A1 3452/4885MAPT 1219/4885HPGD 1382/4885 |
| US-20040053970-A1 | Prenylation inhibitors and methods of their synthesis and use | FNTA, RCE1, GGPS1 | ALDH1A1 3638/4885MAPT 3074/4885HPGD 712/4885 |
| US-20070010561-A1 | PRENYLATION INHIBITORS AND METHODS OF THEIR SYNTHESIS AND USE | FNTA, RCE1, GGPS1 | ALDH1A1 3638/4885MAPT 3074/4885HPGD 712/4885 |
| US-20080119524-A1 | PRENYLATION INHIBITORS CONTAINING DIMETHYLCYCLOBUTANE AND METHODS OF THEIR SYNTHESIS AND USE | RCE1, GGPS1, FNTA | ALDH1A1 3846/4885MAPT 3212/4885HPGD 853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.