Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27565891 | 1.00 | PIN1 (0.47) | PIN1ALDH1A1LMNAPOLBHSD17B10 | |
| SCHEMBL1883119 | 0.87 | PIN1 (0.51) | PIN1ALDH1A1LMNAPOLBHSD17B10 | |
| SCHEMBL6791114 | 0.85 | MC4R (0.50) | PIN1ALDH1A1LMNAPOLBHSD17B10 | |
| SCHEMBL6791119 | 0.85 | MC4R (0.50) | PIN1ALDH1A1LMNAPOLBHSD17B10 | |
| SCHEMBL15485414 | 0.84 | PIN1 (0.49) | PIN1ALDH1A1LMNAPOLBHSD17B10 | |
| SCHEMBL17848997 | 0.84 | CTSL (0.45) | LMNASLC15A1SMN1; SMN2 | |
| SCHEMBL8859231 | 0.82 | LMNA (0.58) | ALDH1A1LMNAHSD17B10TRPM8MEN1 | |
| SCHEMBL5941081 | 0.82 | PIN1 (0.56) | PIN1ALDH1A1LMNAPOLBHSD17B10 | |
| SCHEMBL8732931 | 0.81 | PIN1 (0.45) | PIN1ALDH1A1LMNAPOLBHSD17B10 | |
| SCHEMBL8155355 | 0.81 | PIN1 (0.45) | PIN1ALDH1A1LMNAPOLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967201-B1 | for increasing activation of the 5-HT2C receptor in mammals; treatment of depression, obesity, bulimia, premenstrual syndrome, alcoholism, tobacco abuse, panic disorder | ELI LILLY AND COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-1204654-A1 | BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009111-A1 | BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |