SCHEMBL17848997

SCHEMBL17848997

CC(C)C(N)C(=O)N(CC(=O)OC(C)(C)C)Cc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CTSL P07711 2/20 0.45
CTSB P07858 2/20 0.45
CTSS P25774 2/20 0.45
AKT1 P31749 2/20 0.41
HDAC3 O15379 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC2 Q92769 1/20 0.40
NCOR2 Q9Y618 1/20 0.40
PTGES O14684 1/20 0.40
SLC15A1 P46059 1/20 0.39
RECQL P46063 1/20 0.39
USP2 O75604 1/20 0.38
LMNA P02545 2/20 0.38
HPGD P15428 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6298201 0.84 PIN1 (0.47) SLC15A1LMNASMN1; SMN2
SCHEMBL27565891 0.84 PIN1 (0.47) SLC15A1LMNASMN1; SMN2
SCHEMBL5966898 0.80 SMN1; SMN2 (0.40) SLC15A1SMN1; SMN2
SCHEMBL10423913 0.80 AKT1 (0.42) CTSLCTSBCTSSAKT1HDAC3
SCHEMBL11407459 0.79 MME (0.45) CTSLCTSBCTSS
SCHEMBL8859231 0.78 LMNA (0.58) HDAC1LMNAHPGD
SCHEMBL19567145 0.78 CTSL (0.55) CTSLCTSBCTSSAKT1HDAC3
SCHEMBL11407462 0.77 CTSL (0.44) CTSLCTSBCTSSAKT1HDAC3
SCHEMBL20187564 0.76 AKT1 (0.60) CTSLCTSBCTSSAKT1HDAC3
SCHEMBL782348 0.76 AKT1 (0.55) CTSLCTSBCTSSAKT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3233886-B1 COMPOUNDS IN THE FAMILY OF N-ACYLAMINO-AMIDES, COMPOSITIONS COMPRISING THEM, AND USES OREAL (FR) 2020-02-26 EP disclosed
US-10098827-B2 Compounds in the family of N-acylamino-amides, compositions comprising them, and uses L'OREAL (FR) 2018-10-16 US disclosed
US-20170360667-A1 NEW COMPOUNDS IN THE FAMILY OF N-ACYLAMINO-AMIDES, COMPOSITIONS COMPRISING THEM, AND USES L'OREAL (FR) 2017-12-21 US disclosed
EP-3233886-A1 COMPOUNDS IN THE FAMILY OF N-ACYLAMINO-AMIDES, COMPOSITIONS COMPRISING THEM, AND USES L'Oréal (FR) 2017-10-25 EP disclosed
WO-2016096804-A1 COMPOUNDS IN THE FAMILY OF N-ACYLAMINO-AMIDES, COMPOSITIONS COMPRISING THEM, AND USES L'OREAL (FR) 2016-06-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170360667-A1 NEW COMPOUNDS IN THE FAMILY OF N-ACYLAMINO-AMIDES, COMPOSITIONS COMPRISING THEM, AND USES H1-0, CRY1, CCNA1 CTSL 2977/4885CTSB 1781/4885CTSS 1751/4885
US-10098827-B2 Compounds in the family of N-acylamino-amides, compositions comprising them, and uses CRY1, H1-0, C1R CTSL 3336/4885CTSB 1850/4885CTSS 1860/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.