Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.54 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13909610 | 0.78 | SIGMAR1 (0.59) | SIGMAR1MC4RLMNAPOLBACHE | |
| SCHEMBL220097 | 0.77 | SIGMAR1 (0.62) | SIGMAR1MC4RACHEALDH1A1TDP1 | |
| SCHEMBL31332341 | 0.74 | SIGMAR1 (0.54) | SIGMAR1MC4RACHEALDH1A1TDP1 | |
| SCHEMBL27713375 | 0.73 | SIGMAR1 (0.53) | SIGMAR1MC4RLMNAPOLBACHE | |
| SCHEMBL6138636 | 0.71 | SIGMAR1 (1.00) | SIGMAR1MC4RLMNAPOLBALDH1A1 | |
| SCHEMBL10472337 | 0.71 | SIGMAR1 (0.77) | SIGMAR1MC4RLMNAPOLBACHE | |
| SCHEMBL152631 | 0.71 | SIGMAR1 (1.00) | SIGMAR1MC4RLMNAPOLBALDH1A1 | |
| SCHEMBL276363 | 0.71 | SIGMAR1 (1.00) | SIGMAR1MC4RLMNAPOLBALDH1A1 | |
| SCHEMBL83548 | 0.71 | SIGMAR1 (1.00) | SIGMAR1MC4RLMNAPOLBALDH1A1 | |
| Benzene SCHEMBL27761330 | 0.71 | SIGMAR1 (1.00) | SIGMAR1MC4RLMNAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967201-B1 | for increasing activation of the 5-HT2C receptor in mammals; treatment of depression, obesity, bulimia, premenstrual syndrome, alcoholism, tobacco abuse, panic disorder | ELI LILLY AND COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |