Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.68 |
| ▸ | CXCR4 | P61073 | 9/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.63 |
| ▸ | CCR2 | P41597 | 1/20 | 0.63 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.63 |
| ▸ | MC4R | P32245 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL83548 | 1.00 | SIGMAR1 (1.00) | SIGMAR1MEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL276363 | 1.00 | SIGMAR1 (1.00) | SIGMAR1MEN1KMT2AALDH1A1CYP2C9 | |
| Benzene SCHEMBL27761330 | 1.00 | SIGMAR1 (1.00) | SIGMAR1MEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL152631 | 1.00 | SIGMAR1 (1.00) | SIGMAR1MEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL7062479 | 0.98 | SIGMAR1 (0.96) | SIGMAR1MEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL7573306 | 0.98 | SIGMAR1 (0.96) | SIGMAR1MEN1KMT2AALDH1A1CYP2C9 | |
| Hydrochloric Acid SCHEMBL2223234 | 0.98 | SIGMAR1 (0.96) | SIGMAR1MEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL8145866 | 0.98 | SIGMAR1 (0.96) | SIGMAR1MEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL10063607 | 0.98 | SIGMAR1 (0.96) | SIGMAR1MEN1KMT2AALDH1A1CYP2C9 | |
| Ammonia Solution, Strong SCHEMBL28172574 | 0.98 | SIGMAR1 (0.96) | SIGMAR1MEN1KMT2AALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1277746-B1 | N-benzylpiperazine derivatives, process for their preparation and pharmaceutical compositions thereof | SERVIER LAB (FR) | 2005-05-11 | — | — | EP | disclosed |
| EP-1277746-A3 | N-benzylpiperazine derivatives, process for their preparation and pharmaceutical compositions thereof | Les Laboratoires Servier (FR) | 2003-08-13 | — | — | EP | disclosed |
| EP-1277746-A2 | N-benzylpiperazine derivatives, process for their preparation and pharmaceutical compositions thereof | Les Laboratoires Servier (FR) | 2003-01-22 | — | — | EP | disclosed |