Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 3/20 | 0.32 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SPAST | Q9UBP0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6299334 | 1.00 | PRKCQ (0.36) | PRKCQHTR2CKDM4EALDH1A1GAA | |
| Fumaric Acid SCHEMBL6305107 | 0.82 | HTR2C (0.35) | HTR2CKDM4EALDH1A1GAAMAPT | |
| Fumaric Acid SCHEMBL6305108 | 0.82 | HTR2C (0.35) | HTR2CKDM4EALDH1A1GAAMAPT | |
| Fumaric Acid SCHEMBL6298203 | 0.81 | CA1 (0.39) | HTR2CKDM4EALDH1A1GAAMAPT | |
| Fumaric Acid SCHEMBL6299307 | 0.81 | HTR2C (0.34) | HTR2CKDM4EALDH1A1GAAMAPT | |
| Fumaric Acid SCHEMBL6298202 | 0.81 | CA1 (0.39) | HTR2CKDM4EALDH1A1GAAMAPT | |
| Fumaric Acid SCHEMBL6299304 | 0.81 | HTR2C (0.34) | HTR2CKDM4EALDH1A1GAAMAPT | |
| Fumaric Acid SCHEMBL6298308 | 0.77 | GYS1 (0.36) | KDM4EALDH1A1GAAMAPTSLC6A2 | |
| Fumaric Acid SCHEMBL6298310 | 0.77 | GYS1 (0.36) | KDM4EALDH1A1GAAMAPTSLC6A2 | |
| Fumaric Acid SCHEMBL6298022 | 0.76 | HTR2C (0.44) | HTR2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967201-B1 | for increasing activation of the 5-HT2C receptor in mammals; treatment of depression, obesity, bulimia, premenstrual syndrome, alcoholism, tobacco abuse, panic disorder | ELI LILLY AND COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |