Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.50 |
| ▸ | F2RL1 | P55085 | 3/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3526784 | 0.86 | TAAR1 (0.49) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7518159 | 0.82 | ADRA2C (0.46) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6572921 | 0.82 | ADRA2C (0.46) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11299695 | 0.82 | TAAR1 (0.50) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3530042 | 0.81 | TAAR1 (0.50) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3530217 | 0.80 | TAAR1 (0.39) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11566236 | 0.79 | ADRA2A (0.54) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6299922 | 0.78 | TAAR1 (0.51) | CYP2D6L3MBTL1TAAR1BLMKMT2A | |
| SCHEMBL6299755 | 0.78 | TAAR1 (0.51) | CYP2D6L3MBTL1TAAR1BLMKMT2A | |
| SCHEMBL11289039 | 0.77 | TAAR1 (0.51) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6943183-B2 | 5-substituted tetralones as inhibitors of ras farnesyl transferase | PFIZER INC (US) | 2005-09-13 | — | — | US | disclosed |
| US-20040044057-A1 | 5- substituted tetralones as inhibitors of ras farnesyl trransferase | WARNER-LAMBERT COMPANY | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044057-A1 | 5- substituted tetralones as inhibitors of ras farnesyl trransferase | PTAR1, FNTA, GGPS1 | CYP2D6 1171/4885CYP1A2 893/4885CYP3A4 923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.