Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6294233 | 0.92 | ALDH1A1 (0.62) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL839648 | 0.76 | ALDH1A1 (0.55) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL7008166 | 0.75 | HPGD (0.43) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL11675656 | 0.75 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL12349572 | 0.74 | ALDH1A1 (0.83) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL6795854 | 0.72 | ALDH1A1 (0.40) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL6801095 | 0.72 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL6801223 | 0.72 | ALDH1A1 (0.40) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL6294355 | 0.71 | L3MBTL1 (0.46) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL20704914 | 0.70 | KDM4E (0.59) | ALDH1A1KMT2AMEN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872727-B1 | Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation | PRIVATES INSTITUT FUR BIOMEDIZINISCHE FORSCHUNG UND BERATUNG (DE) | 2005-03-29 | — | — | US | disclosed |
| EP-1150964-B1 | POLYCYCLIC PYRIMIDINE-2,4(1H, 3H)-DIONE WITH FUNCTIONALIZED ALKYL RADICALS IN 1- AND/OR 3-POSITION, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS | IBFB GMBH PRIVATES INST FUER B (DE) | 2003-10-29 | — | — | EP | disclosed |