⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364191 | 0.80 | — | — | |
| SCHEMBL14767571 | 0.79 | HIF1A (0.57) | — | |
| SCHEMBL14767670 | 0.79 | HIF1A (0.57) | — | |
| SCHEMBL10891987 | 0.78 | — | — | |
| SCHEMBL10891979 | 0.78 | — | — | |
| SCHEMBL8670495 | 0.78 | ALOX5 (0.43) | — | |
| SCHEMBL1994157 | 0.77 | — | — | |
| SCHEMBL356407 | 0.75 | — | — | |
| SCHEMBL14767567 | 0.74 | HIF1A (0.56) | — | |
| SCHEMBL17849945 | 0.74 | GPR52 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906069-B1 | Diagnosis indicator; anticholesterol agents; antilipemic agents; antidiabtic agents | AMGEN INC. (US) | 2005-06-14 | — | — | US | claimed |
| US-6906069-B1 | Diagnosis indicator; anticholesterol agents; antilipemic agents; antidiabtic agents | AMGEN INC. (US) | 2005-06-14 | — | — | US | disclosed |
| US-20040152132-A1 | Solid phase synthesis of LXR ligands | TULARIK INC. | 2004-08-05 | — | — | US | disclosed |
| US-6673543-B2 | JOINING LIVER RECEPTORS TO SOLID SUPPORT; GENERATE SOLID SUPPORT, JOIN ANILINE DERIVATIVE TO SUPPORT, INCUBATE WITH ALDEHYE, KETONE, INCUBATE ANILINE DERIVATIVE WITH ACYLATING AGENT, RECOVER SUPPORT | TULARIK, INC. | 2004-01-06 | — | — | US | disclosed |
| US-20020072073-A1 | Solid phase synthesis of LXR ligands | AMGEN INC. | 2002-06-13 | — | — | US | disclosed |