Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP1 | P63208 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29975383 | 0.82 | BACE1 (0.47) | BACE1MMP13ALDH1A1LMNAHRH4 | |
| SCHEMBL27163866 | 0.82 | BACE1 (0.47) | BACE1MMP13ALDH1A1LMNAHRH4 | |
| SCHEMBL29046359 | 0.80 | RAB9A (0.70) | BACE1ALDH1A1LMNAMAPT | |
| SCHEMBL14749300 | 0.77 | MMP13 (0.48) | BACE1MMP13ALDH1A1GPR119SCD5 | |
| SCHEMBL4058660 | 0.77 | GAA (0.64) | CKS1BSKP1SKP2GAAKMT2A | |
| SCHEMBL513725 | 0.76 | MMP13 (0.48) | BACE1MMP13CKS1BSKP1SKP2 | |
| SCHEMBL4926545 | 0.76 | MMP13 (0.55) | BACE1MMP13ALDH1A1MEN1GLA | |
| SCHEMBL30081813 | 0.75 | MEN1 (0.51) | BACE1ALDH1A1MEN1KMT2AGPR119 | |
| SCHEMBL31264982 | 0.75 | BACE1 (0.58) | BACE1ALDH1A1LMNAMAPT | |
| SCHEMBL1458887 | 0.74 | GPR119 (0.76) | CKS1BSKP1SKP2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967201-B1 | for increasing activation of the 5-HT2C receptor in mammals; treatment of depression, obesity, bulimia, premenstrual syndrome, alcoholism, tobacco abuse, panic disorder | ELI LILLY AND COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |
| CN-1365359-A | Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists | LILLY CO ELI (US) | 2002-08-21 | — | — | CN | disclosed |
| EP-1204654-A1 | BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009111-A1 | BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |