Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | STS | P08842 | 3/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1257051 | 0.80 | EPHX2 (0.51) | MMP13RAB9AALDH1A1NPC1HPGD | |
| SCHEMBL1257053 | 0.80 | EPHX2 (0.51) | MMP13RAB9AALDH1A1NPC1HPGD | |
| SCHEMBL1257355 | 0.79 | POLB (0.48) | MMP13RAB9AALDH1A1NPC1HPGD | |
| SCHEMBL14154597 | 0.78 | ALDH1A1 (0.53) | RAB9AALDH1A1NPC1HPGDSMN1; SMN2 | |
| SCHEMBL29200527 | 0.78 | KMT2A (0.52) | RAB9ANPC1STSGPR119PTPN2 | |
| SCHEMBL441012 | 0.76 | KDM4E (0.62) | HPGDSTSGPR119PTPN2PTPN1 | |
| SCHEMBL6300387 | 0.76 | BACE1 (0.56) | MMP13ALDH1A1GPR119HRH4MAPT | |
| SCHEMBL1256910 | 0.76 | HRH4 (0.49) | MMP13RAB9AALDH1A1NPC1HPGD | |
| SCHEMBL1256912 | 0.76 | HRH4 (0.49) | MMP13RAB9AALDH1A1NPC1HPGD | |
| SCHEMBL9003283 | 0.75 | STS (0.54) | HPGDSTSGPR119PTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080176903-A1 | Novel Compounds with Analgesic Effect | ASTRAZENECA CANADA INC. (CA) | 2008-07-24 | — | — | US | disclosed |
| US-20080176903-A1 | Novel Compounds with Analgesic Effect | ASTRAZENECA CANADA INC. (CA) | 2008-07-24 | — | — | US | disclosed |
| US-7312336-B2 | Compounds with analgesic effect | ASTRAZENECA CANADA INC. (CA) | 2007-12-25 | — | — | US | disclosed |
| US-7312336-B2 | Compounds with analgesic effect | ASTRAZENECA CANADA INC. (CA) | 2007-12-25 | — | — | US | disclosed |
| US-7312336-B2 | Compounds with analgesic effect | ASTRAZENECA CANADA INC. (CA) | 2007-12-25 | — | — | US | disclosed |
| EP-0946511-B1 | NOVEL COMPOUNDS WITH ANALGESIC EFFECT | ASTRAZENECA AB (SE) | 2005-05-25 | — | — | EP | disclosed |
| US-20040171612-A1 | Novel compounds with analgesic effect | ASTRAZENECA CANADA INC. | 2004-09-02 | — | — | US | disclosed |
| US-6693117-B2 | PIPERIDIN-4-YLIDENE DERIVATIVES | ASTRAZENECA CANADA INC. (CA) | 2004-02-17 | — | — | US | disclosed |
| US-20030149023-A1 | Novel compounds with analgesic effect | ASTRAZENECA CANADA INC. | 2003-08-07 | — | — | US | disclosed |
| US-6455545-B2 | GASTROINTESTINAL DISORDERS | ASTRAZENECA CANADA INC. (CA) | 2002-09-24 | — | — | US | disclosed |
| US-20010021715-A1 | Novel compounds with analgesic effect | ASTRA PHARMA INC. | 2001-09-13 | — | — | US | disclosed |
| US-6187792-B1 | PIPERIDIN-4-METHYLIDENE-4-BENZAMIDE DERIVATIVES; OPOID RECEPTOR ANTAGONISTS; CANCER PAIN | ASTRA PHARMA INC. (CA) | 2001-02-13 | — | — | US | disclosed |
| EP-0946511-A1 | NOVEL COMPOUNDS WITH ANALGESIC EFFECT | Astra Pharma Inc. (CA) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028275-A1 | NOVEL COMPOUNDS WITH ANALGESIC EFFECT | ASTRA PHARMA INC. (CA) | 1998-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010021715-A1 | Novel compounds with analgesic effect | OPRL1, OPRK1, OPRM1 | MMP13 1694/4885RAB9A 2356/4885ALDH1A1 313/4885 |
| US-20030149023-A1 | Novel compounds with analgesic effect | OPRL1, OPRK1, OPRM1 | MMP13 1694/4885RAB9A 2356/4885ALDH1A1 313/4885 |
| US-20080176903-A1 | Novel Compounds with Analgesic Effect | OPRL1, OPRK1, OPRM1 | MMP13 1337/4885RAB9A 2088/4885ALDH1A1 656/4885 |
| US-20040171612-A1 | Novel compounds with analgesic effect | OPRL1, OPRK1, OPRM1 | MMP13 1694/4885RAB9A 2356/4885ALDH1A1 313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.