Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13869159 | 0.84 | PDPK1 (0.40) | PDPK1MTORMAPTCYP2C19 | |
| SCHEMBL13869157 | 0.84 | PDPK1 (0.40) | PDPK1MTORMAPTCYP2C19 | |
| SCHEMBL28345301 | 0.84 | PDPK1 (0.40) | PDPK1MTORMAPTCYP2C19 | |
| SCHEMBL1578694 | 0.83 | HTR1A (0.39) | — | |
| SCHEMBL8059952 | 0.78 | FUCA1 (0.31) | — | |
| SCHEMBL11380824 | 0.76 | CYP2C19 (0.41) | PDPK1MTORMAPTCYP2C19 | |
| SCHEMBL630321 | 0.76 | ALDH1A1 (0.42) | PDPK1MTORMAPTCYP2C19 | |
| SCHEMBL17898988 | 0.76 | TSHR (0.42) | PDPK1MTORMAPTCYP2C19 | |
| SCHEMBL17265338 | 0.76 | CYP2C19 (0.40) | PDPK1MTORMAPTCYP2C19 | |
| SCHEMBL1579200 | 0.76 | TOP2A (0.35) | PDPK1MTORCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165578-B1 | METHODS AND COMPOSITIONS FOR THE MANUFACTURE OF C-3' AND C-4' ANTHRACYCLINE ANTIBIOTICS | PRIEBE WALDEMAR (US) | 2012-02-22 | — | — | EP | disclosed |
| US-7557090-B2 | Anthracycline antibiotics and methods of treating cancer using the same | HOUSTON PHARMACEUTICALS, INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-20070037758-A1 | administering with a DNA damaging agent; modified alkyl-aromatic ring substitutions on the C-3' of the sugar moiety or alkyl-aromatic ring substitutions at the C-4' of the sugar; cytotoxicity; antitumor, anticarcinogenic agents; multidrug resistance; compounds act by intercalating with DNA | HOUSTON PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | US | disclosed |
| US-6673907-B2 | NOVEL SUBSTITUTED TETRACYCLINES WITH MODIFIED ALKYL-AROMATIC RING SUBSTITUTIONS ON THE C-3' AND/OR C-4' OF THE SUGAR MOIETY; CYTOTOXICITY; ANTITUMOR, -CARCINOGENIC AGENTS; MULTIDRUG RESISTANCE | HOUSTON PHARMACEUTICALS, INC. | 2004-01-06 | — | — | US | disclosed |
| US-20020137694-A1 | Methods and compositions for the manufacture of C-3' and C-4' anthracycline antibiotics | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-09-26 | — | — | US | disclosed |
| EP-1165578-A4 | METHODS AND COMPOSITIONS FOR THE MANUFACTURE OF C-3' AND C-4' ANTHRACYCLINE ANTIBIOTICS | PRIEBE WALDEMAR (US) | 2002-08-28 | — | — | EP | disclosed |
| EP-1165578-A2 | METHODS AND COMPOSITIONS FOR THE MANUFACTURE OF C-3' AND C-4' ANTHRACYCLINE ANTIBIOTICS | Priebe, Waldemar (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056267-A2 | METHODS AND COMPOSITIONS FOR THE MANUFACTURE OF C-3' AND C-4' ANTHRACYCLINE ANTIBIOTICS | PRIEBE WALDEMAR (US) | 2000-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037758-A1 | administering with a DNA damaging agent; modified alkyl-aromatic ring substitutions on the C-3' of the sugar moiety or alkyl-aromatic ring substitutions at the C-4' of the sugar; cytotoxicity; antitumor, anticarcinogenic agents; multidrug resistance; compounds act by intercalating with DNA | PCNA, DDB1, TOP1 | THRB 4340/4885PDPK1 2176/4885MTOR 2253/4885 |
| US-20020137694-A1 | Methods and compositions for the manufacture of C-3' and C-4' anthracycline antibiotics | HCCS, GALE, BCL3 | THRB 4285/4885PDPK1 3040/4885MTOR 694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.