Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | CCKBR | P32239 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13869157 | 1.00 | PDPK1 (0.40) | PDPK1MTORCYP2C19TSHRMAPT | |
| SCHEMBL28345301 | 1.00 | PDPK1 (0.40) | PDPK1MTORCYP2C19TSHRMAPT | |
| SCHEMBL17265338 | 0.91 | CYP2C19 (0.40) | PDPK1MTORCYP2C19TSHRMAPT | |
| SCHEMBL15366804 | 0.89 | TSHR (0.43) | PDPK1MTORCYP2C19TSHRMAPT | |
| SCHEMBL15366807 | 0.89 | TSHR (0.43) | PDPK1MTORCYP2C19TSHRMAPT | |
| SCHEMBL11380824 | 0.89 | CYP2C19 (0.41) | PDPK1MTORCYP2C19TSHRMAPT | |
| SCHEMBL17898988 | 0.88 | TSHR (0.42) | PDPK1MTORCYP2C19TSHRMAPT | |
| SCHEMBL13869160 | 0.86 | CYP2C19 (0.36) | PDPK1MTORCYP2C19TSHRMAPT | |
| SCHEMBL17265241 | 0.86 | CYP2C19 (0.36) | PDPK1MTORCYP2C19TSHRMAPT | |
| SCHEMBL630321 | 0.85 | ALDH1A1 (0.42) | PDPK1MTORCYP2C19TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180002319-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | DOW AGROSCIENCES LLC (US) | 2018-01-04 | — | — | US | disclosed |
| US-20180002320-A1 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2018-01-04 | — | — | US | disclosed |
| US-20180002320-A1 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2018-01-04 | — | — | US | disclosed |
| US-20180002319-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | DOW AGROSCIENCES LLC (US) | 2018-01-04 | — | — | US | disclosed |
| EP-2938190-B1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2017-11-08 | — | — | EP | disclosed |
| EP-2938190-B1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2017-11-08 | — | — | EP | disclosed |
| US-20170273306-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170273306-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170273306-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2017-09-28 | — | — | US | disclosed |
| US-9681664-B2 | Macrocyclic picolinamides as fungicides | DOW AGROSCIENCES LLC (US) | 2017-06-20 | — | — | US | disclosed |
| US-8785479-B2 | Macrocyclic picolinamides as fungicides | DOW AGROSCIENCES, LLC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-8785479-B2 | Macrocyclic picolinamides as fungicides | DOW AGROSCIENCES, LLC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20140187588-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | CORTEVA AGRISCIENCE LLC | 2014-07-03 | — | — | US | disclosed |
| WO-2014105817-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2014-07-03 | — | — | WO | disclosed |
| US-20140187588-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | CORTEVA AGRISCIENCE LLC | 2014-07-03 | — | — | US | disclosed |
| WO-2013169662-A2 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2013-11-14 | — | — | WO | disclosed |
| US-20130296375-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2013-11-07 | — | — | US | disclosed |
| US-20130296375-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2013-11-07 | — | — | US | disclosed |
| US-20130296375-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2013-11-07 | — | — | US | disclosed |
| US-7521568-B2 | Enantiopure 4-deoxypentenosides, dihydropyrans and tetrahydropyrans and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2009-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002320-A1 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | CYP4F12, CYP1A2, CYP4F2 | PDPK1 2196/4885MTOR 1372/4885CYP2C19 47/4885 |
| US-20140187588-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | FKBP14, FKBP2, CYP4F12 | PDPK1 1784/4885MTOR 755/4885CYP2C19 203/4885 |
| US-20130296375-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | FKBP14, FKBP2, CYP51A1 | PDPK1 1689/4885MTOR 598/4885CYP2C19 49/4885 |
| US-20170273306-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | FKBP14, FKBP2, CYP4F12 | PDPK1 1784/4885MTOR 755/4885CYP2C19 203/4885 |
| US-20180002319-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | AADAC, CYP51A1, PFAS | PDPK1 1764/4885MTOR 726/4885CYP2C19 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.