Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6301044 | 0.93 | LTB4R (0.34) | KDM4EALDH1A1TSHRNPSR1L3MBTL1 | |
| SCHEMBL6299856 | 0.91 | LTB4R (0.32) | ALDH1A1LTB4RLTB4R2GABRG2GABRB3 | |
| SCHEMBL6302037 | 0.91 | LTB4R (0.33) | LTB4RLTB4R2GABRG2GABRB3GABRA5 | |
| SCHEMBL6301217 | 0.91 | OPRK1 (0.34) | TSHRLTB4RLTB4R2GABRG2GABRB3 | |
| SCHEMBL6301014 | 0.91 | LTB4R (0.32) | LTB4RLTB4R2GABRG2GABRB3GABRA5 | |
| SCHEMBL6307578 | 0.91 | LTB4R (0.34) | TSHRLTB4RLTB4R2GABRG2GABRB3 | |
| SCHEMBL6307490 | 0.91 | LTB4R (0.34) | TSHRLTB4RLTB4R2GABRG2GABRB3 | |
| SCHEMBL6306424 | 0.90 | LTB4R (0.33) | KDM4EALDH1A1TSHRNPSR1L3MBTL1 | |
| SCHEMBL6302061 | 0.90 | BRD4 (0.33) | ALDH1A1LTB4RLTB4R2GABRG2GABRB3 | |
| SCHEMBL6299942 | 0.89 | L3MBTL1 (0.33) | KDM4EALDH1A1TSHRNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6943183-B2 | 5-substituted tetralones as inhibitors of ras farnesyl transferase | PFIZER INC (US) | 2005-09-13 | — | — | US | disclosed |
| US-20040044057-A1 | 5- substituted tetralones as inhibitors of ras farnesyl trransferase | WARNER-LAMBERT COMPANY | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044057-A1 | 5- substituted tetralones as inhibitors of ras farnesyl trransferase | PTAR1, FNTA, GGPS1 | KDM4E 2646/4885ALDH1A1 578/4885TSHR 1329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.