Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 3/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6296965 | 0.87 | CYP11B1 (0.44) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL6297460 | 0.87 | CYP11B1 (0.44) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL6295828 | 0.86 | CYP11B1 (0.44) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL6295473 | 0.83 | CYP11B1 (0.43) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL6295769 | 0.82 | CYP11B1 (0.43) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL6297055 | 0.81 | DRD2 (0.51) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL6302305 | 0.80 | MAPT (0.49) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL6301560 | 0.75 | ALDH1A1 (0.39) | DRD2DRD4DRD3NSD2GAA | |
| SCHEMBL13424775 | 0.75 | CYP11B1 (0.41) | DRD2DRD4DRD3CYP11B1CYP11B2 | |
| SCHEMBL5638712 | 0.74 | AHR (0.53) | CYP11B1CYP11B2MAOAMAOBKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951855-B2 | Benzoxazinone derivatives for use in the treatment of angiogenesis | ASTRAZENECA AB (SE) | 2005-10-04 | — | — | US | claimed |
| US-20040122006-A1 | Benzoxazinone derivatives for use in the treatment of angiogenesis | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | US | claimed |
| EP-1385835-A1 | BENZOXAZINONE DERIVATIVES FOR USE IN THE TREATMENT OF ANGIOGENESIS | Astrazeneca AB (SE) | 2004-02-04 | — | — | EP | claimed |
| WO-2002085868-A1 | BENZOXAZINONE DERIVATIVES FOR USE IN THE TREATMENT OF ANGIOGENESIS | ASTRAZENECA AB (SE) | 2002-10-31 | — | — | WO | claimed |
| US-6951855-B2 | Benzoxazinone derivatives for use in the treatment of angiogenesis | ASTRAZENECA AB (SE) | 2005-10-04 | — | — | US | disclosed |
| US-20040122006-A1 | Benzoxazinone derivatives for use in the treatment of angiogenesis | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | US | disclosed |
| EP-1385835-A1 | BENZOXAZINONE DERIVATIVES FOR USE IN THE TREATMENT OF ANGIOGENESIS | Astrazeneca AB (SE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002085868-A1 | BENZOXAZINONE DERIVATIVES FOR USE IN THE TREATMENT OF ANGIOGENESIS | ASTRAZENECA AB (SE) | 2002-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122006-A1 | Benzoxazinone derivatives for use in the treatment of angiogenesis | HAX1, VEGFA, HYOU1 | DRD2 2415/4885DRD4 1147/4885DRD3 2234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.