Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 8/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1014096 | 0.85 | KDM4E (0.44) | ALDH1A1HSD17B10KDM4EALOX15MAPT | |
| SCHEMBL28511099 | 0.80 | KDM6B (0.50) | ALDH1A1HSD17B10KDM4EALOX15HCAR3 | |
| SCHEMBL27884460 | 0.80 | HCAR3 (0.49) | ALDH1A1HSD17B10KDM4EALOX15MAPT | |
| SCHEMBL5660785 | 0.78 | ALDH1A1 (0.41) | ALDH1A1HSD17B10KDM4EALOX15MAPT | |
| SCHEMBL9591338 | 0.78 | RGS12 (0.47) | ALDH1A1HSD17B10MAPTCYP1A2CYP2C9 | |
| SCHEMBL240773 | 0.77 | ALDH1A1 (0.52) | ALDH1A1HSD17B10KDM4EALOX15MAPT | |
| Ammonia Solution, Strong SCHEMBL28006349 | 0.77 | ALDH1A1 (0.52) | ALDH1A1HSD17B10KDM4EALOX15MAPT | |
| SCHEMBL4432631 | 0.76 | ALDH1A1 (0.65) | ALDH1A1HSD17B10KDM4EMAPTHCAR3 | |
| Hydrochloric Acid SCHEMBL5140518 | 0.75 | ALDH1A1 (0.50) | ALDH1A1HSD17B10KDM4EALOX15MAPT | |
| SCHEMBL9152373 | 0.73 | RAB9A (0.48) | ALDH1A1ALOX15MAPTCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101460483-B | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor | JANSSEN PHARMACEUTICA NV | 2013-05-08 | — | — | CN | disclosed |
| CN-101460483-A | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-17 | — | — | CN | disclosed |
| US-6875764-B1 | Urea and thiourea compounds useful for treatment of coccidiosis | NEW PHARMA RESEARCH SWEDEN AB (SE) | 2005-04-05 | — | — | US | disclosed |
| EP-1224165-A1 | NOVEL COMPOUNDS | New Pharma Research Sweden AB (SE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001030749-A1 | NOVEL COMPOUNDS | NEW PHARMA RESEARCH SWEDEN AB (SE) | 2001-05-03 | — | — | WO | disclosed |