Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 8/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.38 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.38 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28511099 | 0.88 | KDM6B (0.50) | KDM4EALDH1A1HSD17B10ALOX15HCAR3 | |
| SCHEMBL6302512 | 0.85 | ALDH1A1 (0.47) | KDM4EALDH1A1HSD17B10ALOX15HCAR3 | |
| SCHEMBL5660785 | 0.83 | ALDH1A1 (0.41) | KDM4EALDH1A1HSD17B10ALOX15HCAR3 | |
| SCHEMBL27884460 | 0.77 | HCAR3 (0.49) | KDM4EALDH1A1HSD17B10ALOX15HCAR3 | |
| SCHEMBL1015456 | 0.75 | RAB9A (0.45) | ALDH1A1HSD17B10MAPTCYP1A2CYP2C9 | |
| SCHEMBL19243077 | 0.74 | KDM4E (0.42) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL240773 | 0.74 | ALDH1A1 (0.52) | KDM4EALDH1A1HSD17B10ALOX15HCAR3 | |
| Ammonia Solution, Strong SCHEMBL28006349 | 0.74 | ALDH1A1 (0.52) | KDM4EALDH1A1HSD17B10ALOX15HCAR3 | |
| SCHEMBL5387520 | 0.73 | ADORA3 (0.36) | KDM4EMAPTADORA3SMN1; SMN2 | |
| SCHEMBL5387528 | 0.73 | ADORA3 (0.36) | KDM4EMAPTADORA3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271629-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | AstraZeneca AB (SE) | 2011-01-12 | — | — | EP | disclosed |