Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SDCBP | O00560 | 3/20 | 0.35 |
| ▸ | SDC2 | P34741 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.32 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.32 |
| ▸ | FPR2 | P25090 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314347 | 0.84 | NPSR1 (0.50) | NPSR1ALDH1A1SDCBPSDC2SMN1; SMN2 | |
| SCHEMBL6308358 | 0.83 | MME (0.41) | NPSR1ALDH1A1SDCBPSDC2SMN1; SMN2 | |
| SCHEMBL24837506 | 0.81 | ALDH1A1 (0.41) | NPSR1ALDH1A1SDCBPSDC2SMN1; SMN2 | |
| SCHEMBL6307436 | 0.79 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1FPR2MEN1KMT2A | |
| SCHEMBL4811726 | 0.75 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4811341 | 0.75 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6309635 | 0.75 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6429110 | 0.75 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2PLA2G2APLA2G5L3MBTL1 | |
| SCHEMBL9830441 | 0.74 | FAAH (0.62) | ALDH1A1SMN1; SMN2PLA2G2APLA2G5MEN1 | |
| SCHEMBL9830435 | 0.74 | FAAH (0.62) | ALDH1A1SMN1; SMN2PLA2G2APLA2G5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906058-B2 | 1,5-Benzothiazepines and their use as hypolipidaemics | ASTRAZENECA AB (SE) | 2005-06-14 | — | — | US | disclosed |
| EP-1263747-B1 | 1,5-BENZOTHIAZEPINES AND THEIR USE AS HYPOLIPIDAEMICS | ASTRAZENECA AB (SE) | 2004-11-24 | — | — | EP | disclosed |
| US-20030166927-A1 | 1,5-Benzothiazepines and their use as hypolipidaemics | ALBIREO AB (SE) | 2003-09-04 | — | — | US | disclosed |
| EP-1263747-A1 | 1,5-BENZOTHIAZEPINES AND THEIR USE AS HYPOLIPIDAEMICS | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001066533-A1 | 1,5-BENZOTHIAZEPINES AND THEIR USE AS HYPOLIPIDAEMICS | ASTRAZENECA AB (SE) | 2001-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166927-A1 | 1,5-Benzothiazepines and their use as hypolipidaemics | SLC10A2, SLC10A1, LCAT | NPSR1 1594/4885ALDH1A1 811/4885SDCBP 4266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.