Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | KIF11 | P52732 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | GHSR | Q92847 | 5/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CASR | P41180 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6309838 | 0.92 | CASR (0.53) | EGFRKIF11CYP3A4GHSRPDE4A | |
| SCHEMBL6309040 | 0.87 | PDE4A (0.56) | GHSRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6313871 | 0.83 | KIF11 (0.51) | EGFRKIF11CYP3A4PDE4APDE4B | |
| SCHEMBL6313933 | 0.81 | GHSR (0.52) | GHSRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6314890 | 0.81 | EGFR (0.86) | EGFRCASR | |
| SCHEMBL6314802 | 0.79 | EGFR (0.83) | EGFRCASR | |
| SCHEMBL6313515 | 0.78 | GHSR (0.50) | GHSRMEN1KMT2A | |
| SCHEMBL5878284 | 0.78 | EGFR (0.45) | EGFRKIF11CYP3A4PDE4APDE4B | |
| SCHEMBL7546931 | 0.77 | MEN1 (0.60) | EGFRMEN1KMT2A | |
| SCHEMBL7546935 | 0.77 | MEN1 (0.60) | EGFRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |